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Echinobase
ECB-ART-39302
Pharmazie 2004 Dec 01;5912:965-6.
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Cytotoxic activity of nepetin, a flavonoid from Eupatorium ballotaefolium HBK.

Militão GC , Albuquerque MR , Pessoa OD , Pessoa C , Moraes ME , de Moraes MO , Costa-Lotufo LV .


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The present study evaluated the cytotoxic activity of nepetin and quercetin-3-O-glucoside, compounds isolated from the aerial parts of Eupatorium ballotaefolium. The antimitotic activity was determined as the ability to inhibit sea urchin eggs development and five tumor cells lines growth. Moreover, the activities of these compounds were compared to quercetin in the same models. Nepetin inhibited the proliferation of the five tumor cell lines, once quercetin-3-O-glucoside did not present any activity even at the highest tested concentration and quercetin only inhibited proliferation of the B16 cell line. On the sea urchin assay, nepetin and quercetin induced a dose-dependent inhibition on egg development, while quercetin-3-O-glucoside did not modify normalegg cleavage, even at the highest tested concentration (100 microg/ml).

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Genes referenced: LOC100887844 LOC100893907 LOC115919910