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Genetics
2004 Jun 01;1672:835-50. doi: 10.1534/genetics.103.026187.
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Evidence that the large noncoding sequence is the main control region of maternally and paternally transmitted mitochondrial genomes of the marine mussel (Mytilus spp.).
Cao L
,
Kenchington E
,
Zouros E
,
Rodakis GC
.
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Both the maternal (F-type) and paternal (M-type) mitochondrial genomes of the Mytilus species complex M. edulis/galloprovincialis contain a noncoding sequence between the l-rRNA and the tRNA(Tyr) genes, here called the large unassigned region (LUR). The LUR, which is shorter in M genomes, is capable of forming secondary structures and contains motifs of significant sequence similarity with elements known to have specific functions in the sea urchin and the mammalian control region. Such features are not present in other noncoding regions of the F or M Mytilus mtDNA. The LUR can be divided on the basis of indels and nucleotide variation in three domains, which is reminiscent of the tripartite structure of the mammalian control region. These features suggest that the LUR is the main control region of the Mytilus mitochondrial genome. The middle domain has diverged by only 1.5% between F and M genomes, while the average divergence over the whole molecule is approximately 20%. In contrast, the first domain is among the most divergent parts of the genome. This suggests that different parts of the LUR are under different selection constraints that are also different from those acting on the coding parts of the molecule.
Andrews,
Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA.
1999, Pubmed
Andrews,
Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA.
1999,
Pubmed
Boore,
Animal mitochondrial genomes.
1999,
Pubmed
Brown,
Structural conservation and variation in the D-loop-containing region of vertebrate mitochondrial DNA.
1986,
Pubmed
Burzyński,
Evidence for recombination of mtDNA in the marine mussel Mytilus trossulus from the Baltic.
2003,
Pubmed
Cantatore,
The complete nucleotide sequence, gene organization, and genetic code of the mitochondrial genome of Paracentrotus lividus.
1989,
Pubmed
,
Echinobase
Cantatore,
Mapping and characterization of Paracentrotus lividus mitochondrial transcripts: multiple and overlapping transcription units.
1990,
Pubmed
,
Echinobase
Chang,
Priming of human mitochondrial DNA replication occurs at the light-strand promoter.
1985,
Pubmed
Clary,
The mitochondrial DNA molecular of Drosophila yakuba: nucleotide sequence, gene organization, and genetic code.
1985,
Pubmed
Clary,
Drosophila mitochondrial DNA: conserved sequences in the A + T-rich region and supporting evidence for a secondary structure model of the small ribosomal RNA.
1987,
Pubmed
Clayton,
Transcription and replication of mitochondrial DNA.
2000,
Pubmed
Delport,
Characterization and evolution of the mitochondrial DNA control region in hornbills (Bucerotiformes).
2002,
Pubmed
Doda,
Elongation of displacement-loop strands in human and mouse mitochondrial DNA is arrested near specific template sequences.
1981,
Pubmed
Elliott,
Mutually exclusive synthetic pathways for sea urchin mitochondrial rRNA and mRNA.
1989,
Pubmed
,
Echinobase
Fernandez-Silva,
Sea urchin mtDBP is a two-faced transcription termination factor with a biased polarity depending on the RNA polymerase.
2001,
Pubmed
,
Echinobase
Fisher,
Promoter selection in human mitochondria involves binding of a transcription factor to orientation-independent upstream regulatory elements.
1987,
Pubmed
Goddard,
Origin and direction of replication in mitochondrial DNA molecules from the genus Drosophila.
1980,
Pubmed
Goss,
Detecting heterogeneity of substitution along DNA and protein sequences.
1996,
Pubmed
Hatzoglou,
Complete sequence and gene organization of the mitochondrial genome of the land snail Albinaria coerulea.
1995,
Pubmed
Hoeh,
Cytochrome c oxidase sequence comparisons suggest an unusually high rate of mitochondrial DNA evolution in Mytilus (Mollusca: Bivalvia).
1996,
Pubmed
Hoeh,
Phylogenetic evidence for role-reversals of gender-associated mitochondrial DNA in Mytilus (Bivalvia: Mytilidae).
1997,
Pubmed
Hoffmann,
A novel mitochondrial genome organization for the blue mussel, Mytilus edulis.
1992,
Pubmed
Jacobs,
Nucleotide sequence and gene organization of sea urchin mitochondrial DNA.
1988,
Pubmed
,
Echinobase
Jacobs,
Sea urchin egg mitochondrial DNA contains a short displacement loop (D-loop) in the replication origin region.
1989,
Pubmed
,
Echinobase
Kumar,
MEGA2: molecular evolutionary genetics analysis software.
2001,
Pubmed
Ladoukakis,
Mitochondrial DNA variation in a species with two mitochondrial genomes: the case of Mytilus galloprovincialis from the Atlantic, the Mediterranean and the Black Sea.
2002,
Pubmed
Levinson,
Slipped-strand mispairing: a major mechanism for DNA sequence evolution.
1987,
Pubmed
Lewis,
Sequence, organization, and evolution of the A+T region of Drosophila melanogaster mitochondrial DNA.
1994,
Pubmed
Loguercio Polosa,
Cloning and characterisation of mtDBP, a DNA-binding protein which binds two distinct regions of sea urchin mitochondrial DNA.
1999,
Pubmed
,
Echinobase
Marshall,
Structural conservation and variation in the mitochondrial control region of fringilline finches (Fringilla spp.) and the greenfinch (Carduelis chloris).
1997,
Pubmed
Mayhook,
Replication origins and pause sites in sea urchin mitochondrial DNA.
1992,
Pubmed
,
Echinobase
McDonald,
Improved tests for heterogeneity across a region of DNA sequence in the ratio of polymorphism to divergence.
1998,
Pubmed
Miller,
A simple salting out procedure for extracting DNA from human nucleated cells.
1988,
Pubmed
Okimoto,
The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum.
1992,
Pubmed
Rawson,
The effects of natural hybridization on the regulation of doubly uniparental mtDNA inheritance in blue mussels (Mytilus spp.).
1996,
Pubmed
Rawson,
Evolutionary relationships among the male and female mitochondrial DNA lineages in the Mytilus edulis species complex.
1995,
Pubmed
Ray,
The crocodilian mitochondrial control region: general structure, conserved sequences, and evolutionary implications.
2002,
Pubmed
Roberti,
In vivo mitochondrial DNA-protein interactions in sea urchin eggs and embryos.
1999,
Pubmed
,
Echinobase
Roberti,
Identification of two homologous mitochondrial DNA sequences, which bind strongly and specifically to a mitochondrial protein of Paracentrotus lividus.
1991,
Pubmed
,
Echinobase
Rozas,
DnaSP, DNA polymorphism analyses by the coalescent and other methods.
2003,
Pubmed
Saccone,
Structural elements highly preserved during the evolution of the D-loop-containing region in vertebrate mitochondrial DNA.
1987,
Pubmed
Saccone,
The main regulatory region of mammalian mitochondrial DNA: structure-function model and evolutionary pattern.
1991,
Pubmed
Saccone,
Mitochondrial DNA in metazoa: degree of freedom in a frozen event.
2002,
Pubmed
Saccone,
Evolutionary genomics in Metazoa: the mitochondrial DNA as a model system.
1999,
Pubmed
Saitou,
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
1987,
Pubmed
Sbisà,
Mammalian mitochondrial D-loop region structural analysis: identification of new conserved sequences and their functional and evolutionary implications.
1997,
Pubmed
Serb,
Complete mtDNA sequence of the North American freshwater mussel, Lampsilis ornata (Unionidae): an examination of the evolution and phylogenetic utility of mitochondrial genome organization in Bivalvia (Mollusca).
2003,
Pubmed
Skibinski,
Sex-limited mitochondrial DNA transmission in the marine mussel Mytilus edulis.
1994,
Pubmed
Skibinski,
Mitochondrial DNA inheritance.
1994,
Pubmed
Spruyt,
Complete sequence of the amphioxus (Branchiostoma lanceolatum) mitochondrial genome: relations to vertebrates.
1998,
Pubmed
Stewart,
Male and female mitochondrial DNA lineages in the blue mussel (Mytilus edulis) species group.
1995,
Pubmed
Stoneking,
Hypervariable sites in the mtDNA control region are mutational hotspots.
2000,
Pubmed
Suzuki,
Existence of common homologous elements in the transcriptional regulatory regions of human nuclear genes and mitochondrial gene for the oxidative phosphorylation system.
1991,
Pubmed
Taanman,
The mitochondrial genome: structure, transcription, translation and replication.
1999,
Pubmed
Thompson,
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.
1997,
Pubmed
Tomita,
The cephalopod Loligo bleekeri mitochondrial genome: multiplied noncoding regions and transposition of tRNA genes.
2002,
Pubmed
Valverde,
A conserved heptamer motif for ribosomal RNA transcription termination in animal mitochondria.
1994,
Pubmed
Zouros,
Mitochondrial DNA inheritance.
1994,
Pubmed
Zuker,
Mfold web server for nucleic acid folding and hybridization prediction.
2003,
Pubmed
