Trends Cell Biol 1996 Jul 01;67:245-8. doi: 10.1016/0962-8924(96)20025-x.

ICE/CED-3 proteasesin apoptosis.

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An expanding family of cysteine proteases, of which interleukin-1beta-converting enzyme (ICE) is the prototype, has been shown to play a key role in mammalian cell apoptosis. ICE is both a structural and functional homologue of the nematode ''death gene'' ced-3. Here, Moira Whyte discusses how functional characterization of these ICE-like proteases and identification of their substrates is helping to elucidate the biochemical processes underlying the stereotyped morphology of apoptosis and to identify potential targets for therapy.

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Genes referenced: LOC115919910