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Appl Environ Microbiol
2004 May 01;705:2984-8. doi: 10.1128/AEM.70.5.2984-2988.2004.
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Novel polyketide synthase from Nectria haematococca.
Graziani S
,
Vasnier C
,
Daboussi MJ
.
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We identified a polyketide synthase (PKS) gene, pksN, from a strain of Nectria haematococca by complementing a mutant unable to synthesize a red perithecial pigment. pksN encodes a 2,106-amino-acid polypeptide with conserved motifs characteristic of type I PKS enzymatic domains: beta-ketoacyl synthase, acyltransferase, duplicated acyl carrier proteins, and thioesterase. The pksN product groups with the Aspergillus nidulans WA-type PKSs involved in conidial pigmentation and melanin, bikaverin, and aflatoxin biosynthetic pathways. Inactivation of pksN did not cause any visible change in fungal growth, asexual sporulation, or ascospore formation, suggesting that it is involved in a specific developmental function. We propose that pksN encodes a novel PKS required for the perithecial red pigment biosynthesis.
Altschul,
Basic local alignment search tool.
1990, Pubmed
Altschul,
Basic local alignment search tool.
1990,
Pubmed
Beck,
The multifunctional 6-methylsalicylic acid synthase gene of Penicillium patulum. Its gene structure relative to that of other polyketide synthases.
1990,
Pubmed
Bingle,
Ketosynthase domain probes identify two subclasses of fungal polyketide synthase genes.
1999,
Pubmed
Brown,
Isolation and Characterization of Sexual Spore Pigments from Aspergillus nidulans.
1994,
Pubmed
Chang,
The Aspergillus parasiticus polyketide synthase gene pksA, a homolog of Aspergillus nidulans wA, is required for aflatoxin B1 biosynthesis.
1995,
Pubmed
Crawford,
Characterization of the Heterokaryotic and Vegetative Diploid Phases of MAGNAPORTHE GRISEA.
1986,
Pubmed
Ehrlich,
Promoter elements in the aflatoxin pathway polyketide synthase gene.
2002,
Pubmed
Feng,
Characterization of the polyketide synthase gene (pksL1) required for aflatoxin biosynthesis in Aspergillus parasiticus.
1995,
Pubmed
Fulton,
A melanin polyketide synthase (PKS) gene from Nodulisporium sp. that shows homology to the pks1 gene of Colletotrichum lagenarium.
1999,
Pubmed
Galtier,
SEAVIEW and PHYLO_WIN: two graphic tools for sequence alignment and molecular phylogeny.
1996,
Pubmed
Guadet,
Phylogeny of some Fusarium species, as determined by large-subunit rRNA sequence comparison.
1989,
Pubmed
Hohn,
The Tri4 gene of Fusarium sporotrichioides encodes a cytochrome P450 monooxygenase involved in trichothecene biosynthesis.
1995,
Pubmed
Hopwood,
Molecular genetics of polyketides and its comparison to fatty acid biosynthesis.
1990,
Pubmed
Howe,
Phenotypic diversity among alleles at the per-1 locus of Neurospora crassa.
1976,
Pubmed
Hutchinson,
Microbial polyketide synthases: more and more prolific.
1999,
Pubmed
Kealey,
Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts.
1998,
Pubmed
Keller,
Metabolic Pathway Gene Clusters in Filamentous Fungi
2019,
Pubmed
Keller,
Metabolic pathway gene clusters in filamentous fungi.
1997,
Pubmed
Kurobane,
Metabolites of Fusarium solani related to dihydrofusarubin.
1980,
Pubmed
Lal,
Regulation and manipulation of the gene clusters encoding type-I PKSs.
2000,
Pubmed
Langfelder,
Biosynthesis of fungal melanins and their importance for human pathogenic fungi.
2003,
Pubmed
Langfelder,
Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence.
1998,
Pubmed
Lee,
Polyketide synthase genes in insect- and nematode-associated fungi.
2001,
Pubmed
Linnemannstöns,
The polyketide synthase gene pks4 from Gibberella fujikuroi encodes a key enzyme in the biosynthesis of the red pigment bikaverin.
2002,
Pubmed
Malardier,
Cloning of the nitrate reductase gene (niaD) of Aspergillus nidulans and its use for transformation of Fusarium oxysporum.
1989,
Pubmed
Mayorga,
The developmentally regulated Aspergillus nidulans wA gene encodes a polypeptide homologous to polyketide and fatty acid synthases.
1992,
Pubmed
Metz,
Production of polyunsaturated fatty acids by polyketide synthases in both prokaryotes and eukaryotes.
2001,
Pubmed
Money,
Mechanism linking cellular pigmentation and pathogenicity in rice blast disease.
1997,
Pubmed
Nicholson,
Design and utility of oligonucleotide gene probes for fungal polyketide synthases.
2001,
Pubmed
Orbach,
A cosmid with a HyR marker for fungal library construction and screening.
1994,
Pubmed
Parisot,
Naphthoquinone pigments related to fusarubin from the fungus Fusarium solani (Mart.) Sacc.
1990,
Pubmed
,
Echinobase
Proctor,
A polyketide synthase gene required for biosynthesis of fumonisin mycotoxins in Gibberella fujikuroi mating population A.
1999,
Pubmed
Silar,
Non-conventional infectious elements in filamentous fungi.
1999,
Pubmed
Takano,
Structural analysis of PKS1, a polyketide synthase gene involved in melanin biosynthesis in Colletotrichum lagenarium.
1995,
Pubmed
Yang,
A polyketide synthase is required for fungal virulence and production of the polyketide T-toxin.
1996,
Pubmed
Yu,
Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase.
1995,
Pubmed
Yu,
Comparative mapping of aflatoxin pathway gene clusters in Aspergillus parasiticus and Aspergillus flavus.
1995,
Pubmed
