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Cell Stress Chaperones
2003 Jan 01;81:70-5. doi: 10.1379/1466-1268(2003)8<70:sudita>2.0.co;2.
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Sea urchin deciliation induces thermoresistance and activates the p38 mitogen-activated protein kinase pathway.
Casano C
,
Roccheri MC
,
Maenza L
,
Migliore S
,
Gianguzza F
.
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In this study, we demonstrate by a variety of approaches (ie, morphological analysis, Western blots, immunolocalization, and the use of specific antibodies) that hyperosmotic deciliation stress of sea urchin embryos induces a thermotolerant response. Deciliation is also able to activate a phosphorylation signaling cascade the effector of which might be the p38 stress-activated protein kinase because we found that the administration of the p38 inhibitor SB203580 to sea urchin deciliated gastrula embryos makes the hyperosmotic deciliation stress lethal.
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