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Pflugers Arch
2003 Aug 01;4465:541-52. doi: 10.1007/s00424-003-1076-1.
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Ca2+ signalling and membrane current activated by cADPr in starfish oocytes.
Moccia F
,
Nusco GA
,
Lim D
,
Ercolano E
,
Gragnaniello G
,
Brown ER
,
Santella L
.
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Cyclic ADP-ribose (cADPr) is a second messenger that regulates intracellular free [Ca2+] ([Ca2+](i)) in a variety of cell types, including immature oocytes from the starfish Astropecten auranciacus. In this study, we employed confocal laser scanning microscopy and voltage clamp techniques to investigate the source of the cADPr-elicited Ca2+ wave originating from the cortical Ca2+ patches we have described previously. The Ca2+ swing was accompanied by a membrane current with a reversal potential of approximately +20 mV. Decreasing external Na+ almost abolished the current without affecting the Ca2+ response. Removal of extracellular Ca2+ altered neither the Ca2+ transient nor the ionic current, nor did the holding potential exert any effect on the Ca2+ wave. Both the Ca2+ response and the membrane current were abolished when BAPTA, ruthenium red or 8-NH(2)-cADPr were preinjected into the oocytes, while perfusion with ADPr did not elicit any [Ca2+](i) increase or ionic current. However, elevating [Ca2+](i) by uncaging Ca2+ from nitrophenyl- (NP-EGTA) or by photoliberating inositol 1,4,5-trisphosphate (InsP(3)) induced an ionic current with biophysical properties similar to that elicited by cADPr. These results suggest that cADPr activates a Ca2+ wave by releasing Ca2+ from intracellular ryanodine receptors and that the rise in [Ca2+](i) triggers a non-selective monovalent cation current that does not seem to contribute to the global Ca2+ elevation.
Albrieux,
Calcium signaling by cyclic ADP-ribose, NAADP, and inositol trisphosphate are involved in distinct functions in ascidian oocytes.
1998, Pubmed
Albrieux,
Calcium signaling by cyclic ADP-ribose, NAADP, and inositol trisphosphate are involved in distinct functions in ascidian oocytes.
1998,
Pubmed
Albrieux,
Calmodulin and immunophilin are required as functional partners of a ryanodine receptor in ascidian oocytes at fertilization.
2000,
Pubmed
Albrieux,
The two intracellular Ca2+ release channels, ryanodine receptor and inositol 1,4,5-trisphosphate receptor, play different roles during fertilization in ascidians.
1997,
Pubmed
Ashby,
Localized Ca2+ uncaging reveals polarized distribution of Ca2+-sensitive Ca2+ release sites: mechanism of unidirectional Ca2+ waves.
2002,
Pubmed
Berridge,
Solubilization of receptors for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate.
2002,
Pubmed
,
Echinobase
Borra,
Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases.
2002,
Pubmed
Cancela,
Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
2000,
Pubmed
Cancela,
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
1999,
Pubmed
,
Echinobase
Cancela,
Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers.
2002,
Pubmed
Carafoli,
Generation, control, and processing of cellular calcium signals.
2001,
Pubmed
Churchill,
NAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ stores.
2001,
Pubmed
,
Echinobase
Crawford,
Activation of Ca2+-dependent currents in dorsal root ganglion neurons by metabotropic glutamate receptors and cyclic ADP-ribose precursors.
1997,
Pubmed
Currie,
Activation of Ca(2+)-dependent currents in cultured rat dorsal root ganglion neurones by a sperm factor and cyclic ADP-ribose.
1992,
Pubmed
,
Echinobase
Giovannucci,
Cytosolic Ca(2+) and Ca(2+)-activated Cl(-) current dynamics: insights from two functionally distinct mouse exocrine cells.
2002,
Pubmed
Guia,
Local Ca2+ entry through L-type Ca2+ channels activates Ca2+-dependent K+ channels in rabbit coronary myocytes.
1999,
Pubmed
Guo,
Cyclic ADP-ribose-gated Ca2+ release in sea urchin eggs requires an elevated.
1997,
Pubmed
,
Echinobase
Guse,
Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP): novel regulators of Ca2+-signaling and cell function.
2002,
Pubmed
Guse,
Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose.
1999,
Pubmed
Guse,
Ca2+ entry induced by cyclic ADP-ribose in intact T-lymphocytes.
1997,
Pubmed
Hagiwara,
Effects of internal potassium and sodium on the anomalous rectification of the starfish egg as examined by internal perfusion.
1979,
Pubmed
,
Echinobase
Ito,
Kinetic control of multiple forms of Ca(2+) spikes by inositol trisphosphate in pancreatic acinar cells.
1999,
Pubmed
Kidd,
Intracellular Ca2+ and Cl- channel activation in secretory cells.
2000,
Pubmed
Kidd,
The role of Ca2+ feedback in shaping InsP3-evoked Ca2+ signals in mouse pancreatic acinar cells.
1999,
Pubmed
Kiselyov,
Regulation of Ca2+-release-activated Ca2+ current (Icrac) by ryanodine receptors in inositol 1,4,5-trisphosphate-receptor-deficient DT40 cells.
2001,
Pubmed
Kockskämper,
Activation and propagation of Ca(2+) release during excitation-contraction coupling in atrial myocytes.
2001,
Pubmed
Krause,
Cell side-specific sensitivities of intracellular Ca2+ stores for inositol 1,4,5-trisphosphate, cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate in permeabilized pancreatic acinar cells from mouse.
2002,
Pubmed
Lansman,
Calcium current and calcium-activated inward current in the oocyte of the starfish Leptasterias hexactis.
1987,
Pubmed
,
Echinobase
Lansman,
Voltage-clamp study of the conductance activated at fertilization in the starfish egg.
1983,
Pubmed
,
Echinobase
Lee,
Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers.
2001,
Pubmed
Lim,
NAADP+ initiates the Ca2+ response during fertilization of starfish oocytes.
2001,
Pubmed
,
Echinobase
Mackenzie,
The role of inositol 1,4,5-trisphosphate receptors in Ca(2+) signalling and the generation of arrhythmias in rat atrial myocytes.
2002,
Pubmed
Maruyama,
Cholecystokinin activation of single-channel currents is mediated by internal messenger in pancreatic acinar cells.
1982,
Pubmed
Mészáros,
Cyclic ADP-ribose as an endogenous regulator of the non-skeletal type ryanodine receptor Ca2+ channel.
1993,
Pubmed
,
Echinobase
Miyazaki,
Potassium rectifications of the starfish oocyte membrane and their changes during oocyte maturation.
1975,
Pubmed
,
Echinobase
Miyazaki,
Action potential and non-linear current-voltage relation in starfish oocytes.
1975,
Pubmed
,
Echinobase
Moody,
Developmental regulation of Ca2+ and K+ currents during hormone-induced maturation of starfish oocytes.
1983,
Pubmed
,
Echinobase
Moody,
Hormone-induced loss of surface membrane during maturation of starfish oocytes: differential effects on potassium and calcium channels.
1985,
Pubmed
,
Echinobase
Morikawa,
Two intracellular pathways mediate metabotropic glutamate receptor-induced Ca2+ mobilization in dopamine neurons.
2003,
Pubmed
Nusco,
Ca(2+) response to cADPr during maturation and fertilization of starfish oocytes.
2002,
Pubmed
,
Echinobase
Park,
Local uncaging of caged Ca(2+) reveals distribution of Ca(2+)-activated Cl(-) channels in pancreatic acinar cells.
2001,
Pubmed
Pollock,
Metabotropic glutamate receptor activation and intracellular cyclic ADP-ribose release Ca2+ from the same store in cultured DRG neurones.
1999,
Pubmed
Rusinko,
Widespread occurrence in animal tissues of an enzyme catalyzing the conversion of NAD+ into a cyclic metabolite with intracellular Ca2+-mobilizing activity.
1989,
Pubmed
,
Echinobase
Ryan,
Purinergic regulation of cation conductances and intracellular Ca2+ in cultured rat retinal pigment epithelial cells.
1999,
Pubmed
Santella,
Effects of 1-methyladenine on nuclear Ca2+ transients and meiosis resumption in starfish oocytes are mimicked by the nuclear injection of inositol 1,4,5-trisphosphate and cADP-ribose.
1997,
Pubmed
,
Echinobase
Santella,
Nicotinic acid adenine dinucleotide phosphate-induced Ca(2+) release. Interactions among distinct Ca(2+) mobilizing mechanisms in starfish oocytes.
2000,
Pubmed
,
Echinobase
Santella,
Cortical granule translocation during maturation of starfish oocytes requires cytoskeletal rearrangement triggered by InsP3-mediated Ca2+ release.
1999,
Pubmed
,
Echinobase
Santella,
Activated M-phase-promoting factor (MPF) is exported from the nucleus of starfish oocytes to increase the sensitivity of the Ins(1,4,5)P3 receptors.
2003,
Pubmed
,
Echinobase
Simoncini,
Changes in voltage-dependent currents and membrane area during maturation of starfish oocytes: species differences and similarities.
1990,
Pubmed
,
Echinobase
Sitsapesan,
Cyclic ADP-ribose and related compounds activate sheep skeletal sarcoplasmic reticulum Ca2+ release channel.
1995,
Pubmed
Stricker,
Calcium dynamics during starfish oocyte maturation and fertilization.
1994,
Pubmed
,
Echinobase
Thomas,
Calmodulin dissociation mediates desensitization of the cADPR-induced Ca2+ release mechanism.
2002,
Pubmed
,
Echinobase
Thomas,
Depolarisation-evoked Ca2+ waves in the non-excitable rat megakaryocyte.
2001,
Pubmed
Wilding,
ADP-ribose gates the fertilization channel in ascidian oocytes.
1998,
Pubmed
Yang,
Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.
2002,
Pubmed
