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Echinobase
ECB-ART-38054
Toxicol Sci 2003 May 01;731:141-8. doi: 10.1093/toxsci/kfg043.
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Effect of organochlorine pesticides on maturation of starfish and mouse oocytes.

Picard A , Pahlavan G , Palavan G , Robert S , Pesando D , Ciapa B .


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Methoxychlor, lindane, and dieldrin are organochlorine pesticides that have been described as altering different reproductive functions in mammals and in invertebrates. However, few data have been published concerning the effects these pesticides have on oocyte maturation and fertilization. The aim of this study was to determine whether these compounds could affect maturation of mouse and starfish oocytes. We observed that germinal vesicle breakdown (GVBD) in starfish oocytes was significantly inhibited by the pesticides. Furthermore, formation of the first meiotic spindle and extrusion of the first polar body were also altered in mouse as well as in starfish. Our results suggest that the three pesticides act on common intracellular targets in invertebrates as well as in vertebrates.

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Genes referenced: LOC590297
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