ECB-ART-37941
J Nat Prod
2001 Sep 01;649:1169-73. doi: 10.1021/np010066n.
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Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species.
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Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.
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Genes referenced: LOC100887844