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Genome Biol
2001 Jan 01;25:REVIEWS1015. doi: 10.1186/gb-2001-2-5-reviews1015.
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Morpholino antisense oligonucleotides: tools for investigating vertebrate development.
Corey DR
,
Abrams JM
.
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Antisense oligonucleotides provide a promising approach to investigating gene function in vivo, but their ability to offer unambiguous insights into phenotypes has been debated. The recent use of morpholino antisense oligonucleotides in zebrafish embryos may prove a major advance, but rigorous controls are essential.
Figure 1. Structures of DNA and morpholino oligonucleotides. R and R' denote continuation of the oligomer chain in the 5' or 3' direction, respectively.
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