ECB-ART-37668
Biochem Biophys Res Commun
2000 Dec 29;2793:832-7. doi: 10.1006/bbrc.2000.4042.
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A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE motifs.
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Kinases of the CDC2 family play a key role in cell cycle regulation and gene expression. In the present work, we identified sea urchin and human cDNAs encoding homologues of a high molecular mass CDC2-like kinase (designated CDC2L5) sharing respectively a PITAVRE and PITAIRE motif. The human cDNA encodes the full-length amino acid sequence of the cholinesterase-related cell division controller (CHED) kinase, a previously published partial coding sequence. CDC2L5 overexpressed in mammalian cells is an approximately 170-kDa nuclear protein. The mRNA is present during the sea urchin early embryogenesis and is ubiquitously expressed in human tissues.
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Genes referenced: cdk13 LOC100887844 LOC115919856 LOC115919910