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ECB-ART-37548
J Theor Biol 2000 Oct 07;2063:419-28. doi: 10.1006/jtbi.2000.2134.
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What does a common channel for electrolytes and non-electrolytes in the sperm mean?

Sitaramam V , Sauna ZE .


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Cell volume is central to osmoregulation in intact cells. Bovine spermatozoa, as also other mammalian spermatozoa, exhibit a very rapid regulatory volume decrease (RVD) when exposed to hypotonic saline media. This response, fastest known in animal cells, is mediated by a putative potassium channel which the pharmacological properties of a conventional channel and yet admits both electrolytes and non-electrolytes. The evolutionary basis and functional role of this conserved quinine-sensitive channel in mammalian sperm could offer hitherto unexplored facets of the link(s) between ecology and reproduction.

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Genes referenced: LOC115919910 LOC115924212