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ECB-ART-37542
Bioorg Med Chem 2000 Jul 01;87:1757-66. doi: 10.1016/s0968-0896(00)00110-3.
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Synthesis and biological activities of the marine bryozoan alkaloids convolutamines A, C and F, and lutamides A and C.

Hashima H , Hayashi M , Kamano Y , Sato N .


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Synthesis of convolutamines and lutamides, new 2,4,6-tribromo-3-methoxyphenethylamine alkaloids isolated from Floridian marine bryozoan Amathia convoluta, was accomplished by a sequence of reactions starting from 3-hydroxyphenethylamines. Cytotoxities of the synthetic lutamides, convolutamines and their de-O-methyl derivatives were examined using drug-sensitive and -resistant P388 as well as KB cell lines. The bioassay suggests that the 2,4,6-tribromo-3-methoxyphenethylamine is an indispensable unit for detection of the activities. Additionally, a reversal of drug resistance by those alkaloids is recognized.

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Genes referenced: LOC100893907 LOC115919910