ECB-ART-37502
J Nat Prod
2000 Jul 01;637:981-3. doi: 10.1021/np990408d.
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Matemone, a new bioactive bromine-containing oxindole alkaloid from the indian ocean sponge Iotrochota purpurea.
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A new bioactive bromine-containing oxindole alkaloid, matemone (1), was isolated from the Indian Ocean sponge Iotrochota purpurea, together with the known 6-bromoindole-3-carbaldehyde. The structures were elucidated on the basis of spectral and chemical data. Compound 1 shows mild cytotoxicity against three cancer cell lines and marginal antibacterial activity against Staphyloccocus aureus. DNA intercalant screening demonstrated DNA interactions with 1. Both compounds inhibit division of sea-urchin eggs.
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Genes referenced: LOC100887844 LOC100893907 LOC115919910