ECB-ART-37411
Bioorg Med Chem Lett
2000 Mar 20;106:567-9. doi: 10.1016/s0960-894x(00)00048-2.
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2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity.
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9-Trifluoromethyl-paullones with a carbon chain in the 2-position were synthesized by palladium-catalyzed coupling reactions of a 2-iodoprecursor with terminal alkenes or alkynes, respectively. The introduction of a 2-cyanoethyl substituent led to a significant enhancement of CDK1/cyclin B inhibiting property and in vitro antiproliferative activity.
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Genes referenced: cdk1