ECB-ART-37374
Oncol Rep
2000 Jan 01;72:397-400. doi: 10.3892/or.7.2.397.
Show Gene links
Show Anatomy links
Efficacy and safety profile of amifostine in the preoperative combined therapy of esophageal cancer patients.
???displayArticle.abstract???
The aim of this study was to assess the protective effect and the safety profile of amifostine in 16 esophageal cancer patients undergoing neoadjuvant chemo-radiation therapy (group A) compared to 21 matched patients (group B), treated with the same schedule without receiving amifostine, and considered as controls. Haematological and extra-haematological toxicity were evaluated according to WHO criteria and considered as result of amifostine activity. The bone marrow toxicity was globally lower in group A than in group B. We recorded 4 cases of mucosities in group B compared to 1 case in group A. amifostine-related side effects were few (2 cases of hypotension and 1 of vomiting), mild, and well controlled. In conclusion, amifostine seems to be effective and safe when used as protective agent also in esophageal cancer.
???displayArticle.pubmedLink??? 10671693
???displayArticle.link??? Oncol Rep