Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-37075
Bioorg Med Chem Lett 1998 Apr 07;87:793-8. doi: 10.1016/s0960-894x(98)00097-3.
Show Gene links Show Anatomy links

Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases.

Legraverend M , Ludwig O , Bisagni E , Leclerc S , Meijer L .


???displayArticle.abstract???
The synthesis of a new family of inhibitors of the cell cycle regulating cyclin-dependent kinases (CDK''s) is reported. These compounds, related to the purines olomoucine and roscovitine, are characterised by the presence of alkynylated side chains at C2. They inhibit CDK''s with IC50''s in the 200 nM range.

???displayArticle.pubmedLink??? 9871543
???displayArticle.link??? Bioorg Med Chem Lett


Genes referenced: LOC115919910