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Biochem J
1998 Nov 01;335 ( Pt 3):499-504. doi: 10.1042/bj3350499.
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Differential effect of pH upon cyclic-ADP-ribose and nicotinate-adenine dinucleotide phosphate-induced Ca2+ release systems.
Chini EN
,
Liang M
,
Dousa TP
.
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We investigated the pH dependence and the effects of thimerosal and dithiothreitol (DTT) upon the Ca2+ release induced by cADP-ribose (cADPR) and nicotinate-adenine dinucleotide phosphate (NAADP) in sea urchin egg homogenates. Both Ca2+ release triggered by cADPR and the binding of [3H]cADPR to sea urchin egg homogenates were decreased by alkalization of the assay media from pH 7.2 to 8.9. In contrast, NAADP-triggered Ca2+ release was not influenced by changes in pH. The Ca2+ release induced by cADPR was potentiated by thimerosal and inhibited by DTT, but neither thimerosal nor DTT had any effect upon the Ca2+ release induced by NAADP. We conclude that cADPR-sensitive Ca2+-release mechanisms are dependent on pH of the assay media and are sensitive to thiol group modification. On the other hand, these functional properties are not shared by NAADP-regulated Ca2+ channels.
Aarhus,
Activation and inactivation of Ca2+ release by NAADP+.
1996, Pubmed,
Echinobase
Aarhus,
Activation and inactivation of Ca2+ release by NAADP+.
1996,
Pubmed
,
Echinobase
Berridge,
The biology and medicine of calcium signalling.
1994,
Pubmed
Bootman,
The thiol reagent, thimerosal, evokes Ca2+ spikes in HeLa cells by sensitizing the inositol 1,4,5-trisphosphate receptor.
1992,
Pubmed
Brunder,
Heavy metal-induced Ca2+ release from sarcoplasmic reticulum.
1988,
Pubmed
Chini,
Nicotinate adenine dinucleotide phosphate (NAADP) triggers a specific calcium release system in sea urchin eggs.
1995,
Pubmed
,
Echinobase
Chini,
Specific modulation of cyclic ADP-ribose-induced Ca2+ release by polyamines.
1995,
Pubmed
,
Echinobase
Chini,
Nicotinate-adenine dinucleotide phosphate-induced Ca(2+)-release does not behave as a Ca(2+)-induced Ca(2+)-release system.
1996,
Pubmed
,
Echinobase
Chini,
Palmitoyl-CoA potentiates the Ca2+ release elicited by cyclic ADP-ribose.
1996,
Pubmed
,
Echinobase
Ciapa,
Cell-cycle calcium transients driven by cyclic changes in inositol trisphosphate levels.
1994,
Pubmed
,
Echinobase
Clapham,
Calcium signaling.
1995,
Pubmed
Coronado,
Structure and function of ryanodine receptors.
1994,
Pubmed
Darszon,
Ion channels: key elements in gamete signaling.
1996,
Pubmed
Dousa,
Adenine nucleotide diphosphates: emerging second messengers acting via intracellular Ca2+ release.
1996,
Pubmed
,
Echinobase
Epel,
The initiation of development at fertilization.
1990,
Pubmed
,
Echinobase
Favero,
Hydrogen peroxide stimulates the Ca2+ release channel from skeletal muscle sarcoplasmic reticulum.
1995,
Pubmed
Galione,
Ca2+ release induced by cyclic ADP-ribose.
1994,
Pubmed
Galione,
Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose.
1991,
Pubmed
,
Echinobase
Galione,
cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis.
1993,
Pubmed
,
Echinobase
Genazzani,
Unique inactivation properties of NAADP-sensitive Ca2+ release.
1996,
Pubmed
,
Echinobase
Genazzani,
Nicotinic acid-adenine dinucleotide phosphate mobilizes Ca2+ from a thapsigargin-insensitive pool.
1996,
Pubmed
,
Echinobase
Genazzani,
Kinetic properties of nicotinic acid adenine dinucleotide phosphate-induced Ca2+ release.
1997,
Pubmed
,
Echinobase
Genazzani,
Pharmacological properties of the Ca2+-release mechanism sensitive to NAADP in the sea urchin egg.
1997,
Pubmed
,
Echinobase
Genazzani,
A Ca2+ release mechanism gated by the novel pyridine nucleotide, NAADP.
1997,
Pubmed
,
Echinobase
Graeff,
Magnesium ions but not ATP inhibit cyclic ADP-ribose-induced calcium release.
1995,
Pubmed
,
Echinobase
Guillemette,
Effects of pH, reducing and alkylating reagents on the binding and Ca2+ release activities of inositol 1,4,5-triphosphate in the bovine adrenal cortex.
1988,
Pubmed
Hellmich,
Purification and characterization of a molluscan egg-specific NADase, a second-messenger enzyme.
1991,
Pubmed
,
Echinobase
Hilly,
Thiol reagents increase the affinity of the inositol 1,4,5-trisphosphate receptor.
1993,
Pubmed
Iino,
Calcium-induced calcium release mechanism in guinea pig taenia caeci.
1989,
Pubmed
Kusunoki,
Cyclic change in polyamine concentrations in sea urchin eggs related with cleavage cycle.
1976,
Pubmed
,
Echinobase
Lee,
Wide distribution of an enzyme that catalyzes the hydrolysis of cyclic ADP-ribose.
1993,
Pubmed
,
Echinobase
Lee,
A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose.
1995,
Pubmed
,
Echinobase
Lee,
Specific binding of cyclic ADP-ribose to calcium-storing microsomes from sea urchin eggs.
1991,
Pubmed
,
Echinobase
Lee,
Cyclic ADP-ribose: a calcium mobilizing metabolite of NAD+.
1994,
Pubmed
,
Echinobase
Lee,
Potentiation of calcium- and caffeine-induced calcium release by cyclic ADP-ribose.
1993,
Pubmed
,
Echinobase
Perez-Terzic,
Ca2+ release triggered by nicotinate adenine dinucleotide phosphate in intact sea urchin eggs.
1995,
Pubmed
,
Echinobase
Poenie,
Changes of free calcium levels with stages of the cell division cycle.
1985,
Pubmed
,
Echinobase
Sayers,
The effects of thimerosal on calcium uptake and inositol 1,4,5-trisphosphate-induced calcium release in cerebellar microsomes.
1993,
Pubmed
Shen,
A synthetic peptide of the pseudosubstrate domain of protein kinase C blocks cytoplasmic alkalinization during activation of the sea urchin egg.
1990,
Pubmed
,
Echinobase
Shen,
Na+-H+ antiport during fertilization of the sea urchin egg is blocked by W-7 but is insensitive to K252a and H-7.
1989,
Pubmed
,
Echinobase
Tanaka,
Thimerosal potentiates Ca2+ release mediated by both the inositol 1,4,5-trisphosphate and the ryanodine receptors in sea urchin eggs. Implications for mechanistic studies on Ca2+ signaling.
1994,
Pubmed
,
Echinobase
Walseth,
Identification of cyclic ADP-ribose-binding proteins by photoaffinity labeling.
1993,
Pubmed
,
Echinobase
Worley,
Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium.
1987,
Pubmed
