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ECB-ART-36888
J Nat Prod 1998 Mar 27;613:370-4. doi: 10.1021/np970429c.
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New Sulfated Polyhydroxysteroids from the Antarctic Ophiuroid Astrotomaagassizii

Roccatagliata AJ , Maier MS , Seldes AM .


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Three new and two known sulfated steroidal polyols have been isolated from the Antarctic ophiuroid Astrotoma agassizii. All of the new steroids possess a terminal isopropenyl group and a C-21 sulfoxy moiety in the side chain but differ in the steroidal nuclei. The structures of these new steroids were established from spectral and chemical correlations with related steroids as (20R)-cholesta-5,24-diene-2beta,3alpha,21-triol 2,21-disulfate (1), (20R)-5alpha-cholest-24-ene-2beta,3alpha,21-triol 3,21-disulfate (3), and (20R)-cholesta-5,24-diene-2alpha,3alpha,4beta,21-tetrol 3,21-disulfate (5). Analysis of the nonsulfated sterol fraction has shown the presence of cholest-5-en-3beta-ol, cholesta-5,24-dien-3beta-ol and (22E) cholesta-5,22-dien-3beta-ol as the major sterols.

???displayArticle.pubmedLink??? 9548877
???displayArticle.link??? J Nat Prod