ECB-ART-36321
Z Naturforsch C J Biosci
1996 Jan 01;513-4:233-42. doi: 10.1515/znc-1996-3-415.
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A cytotoxic principle of Tamarindus indica, di-n-butyl malate and the structure-activity relationship of its analogues.
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Bioassay-guided fractionation of the methanolic extract of Tamarindus indica fruits led to the isolation of L-(-)-di-n-butyl malate which exhibited a pronounced cytotoxic activity against sea urchin embryo cells. In order to study structure-activity relationships, close-structure relatives of di-n-butyl malate were synthesized using D-(+)- and L-(-)-malic acid as starting materials, and their cytotoxic activities were examined for the sea urchin embryo assay. L-(-)-Di-n-pentyl malate was the most effective inhibitor to the development of the fertilized eggs. Significant inhibitory activity was not seen in the esters of D-(-)-isomer.
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Genes referenced: LOC100887844