Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-35912
Proc Natl Acad Sci U S A 1994 Nov 22;9124:11567-70. doi: 10.1073/pnas.91.24.11567.
Show Gene links Show Anatomy links

Low levels of exogenous histone H1 in yeast cause cell death.

Miloshev G , Venkov P , van Holde K , Zlatanova J .


???displayArticle.abstract???
To elucidate the function of lysine-rich histone, yeast cells, which are believed to lack this histone, were transformed with an expression vector carrying the sea urchin histone H1 gene under control of an inducible promoter. Expression of full-length protein was tested by immunoblotting and the intracellular distribution was monitored by immunoelectron microscopy. Even low amounts of exogenous H1 led to dramatic changes in intracellular morphology and cell death. The cells that survived had lost either the plasmid or the ability to express the exogenous protein. Thus, even low amounts of canonical histone H1 are lethal to yeast cells.

???displayArticle.pubmedLink??? 7972103
???displayArticle.pmcLink??? PMC45272
???displayArticle.link??? Proc Natl Acad Sci U S A
???displayArticle.grants??? [+]

Genes referenced: LOC100887844 LOC115919910 LOC579470

References [+] :
Bates, Histones H1 and H5: one or two molecules per nucleosome? 1981, Pubmed