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Echinobase
ECB-ART-35878
Mol Cell Biochem 1994 Sep 01;1381-2:229-35. doi: 10.1007/bf00928466.
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Cyclic ADP-ribose: a calcium mobilizing metabolite of NAD+.

Lee HC .


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Mobilization of Ca+2 from intracellular stores is a signalling mechanism that is of fundamental importance to many cellular processes. It is mediated by two major mechanisms, the inositol 1,4,5-trisphosphate pathway and the Ca+2-induced Ca+2 release process. A naturally occurring metabolite of NAD+ called cyclic ADP-ribose has been discovered recently and shown to be as effective as inositol 1,4,5-trisphosphate in mobilizing Ca+2 stores in sea urchin eggs, a marine invertebrate cell, as well as several mammalian cells. This article reviews the accumulating evidence that indicates cyclic ADP-ribose may function as a physiological regulator of the Ca+2-induced Ca+2 release process and the current knowledge about its receptor as well as the enzymes involved in its metabolism.

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Genes referenced: LOC100887844 LOC115919910

References [+] :
Berridge, Inositol trisphosphate and calcium signalling. 1993, Pubmed