Biochem Biophys Res Commun 1995 Mar 08;2081:204-9. doi: 10.1006/bbrc.1995.1324.

Differential phosphorylation of a 57-KDa protein tyrosine kinase during egg activation.

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Fertilization results in activation of many protein kinases which function during egg activation. We have used metabolic labelling and immunoprecipitation to study changes in the phosphorylation state of a 57-KDa src-family protein tyrosine kinase during fertilization of the sea urchin egg. The kinase was phosphorylated on serine at all periods studied but it was also phosphorylated transiently on tyrosine at 5 minutes post insemination and then on threonine at 90 minutes after fertilization. These data indicate that the 57-KDa PTK may be under complex regulatory control during the first cell cycle.

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Genes referenced: LOC100887844 LOC115919758 LOC115919910 LOC574936