Antibiotiki 1980 Jun 01;256:408-11.

[Triterpene glycosides with antifungal activity isolated from the sea cucumber, Cucumaria japonica].

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A complex of triterpenic oligoglycosides or cucumariosides was isolated from the skin-muscular sac of Cucumaria japonica. The complex includes at least 7 components. Fractionation of the complex on lyophilized sephadex LH-20 resulted in quantitative isolation of its 2 main components, i.e. cucumariosides I and II in a chromatographically pure state. The part of these glucosides in the native mixture of cucumariosides was 65 and 20% respectively. The complex inhibited the growth of Candida albicans and C. tropicalis in concentrations of 50 microgram/ml. Cucumarioside II inhibited the growth of the above organisms in a concentration of 60 microgram/ml. The MIC of I for these organisms was 30 and 40 microgram/ml respectively.

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Genes referenced: adcy10 LOC100887844