Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
A model for the effects of potential and external K+ concentration on the Cs+ blocking of inward rectification.
Ciani S
,
Krasne S
,
Hagiwara S
.
???displayArticle.abstract???
Inward rectification in starfish egg cell membranes is blocked by external Cs+, the degree of blocking being an increasing function of hyperpolarizing potentials and of the external concentration of K+. While the effect of K+ and the particular functional dependence of blocking on potential are difficult to reconcile with a one-ion pore model, both features can be accounted for assuming that the pore has at least two sites and tat a considerable fraction of the blocked pores is simultaneously occupied by a Cs+ ion in the inner site and by a K+ in the outer one.
Cahalan,
Sodium channel selectivity. Dependence on internal permeant ion concentration.
1976, Pubmed
Cahalan,
Sodium channel selectivity. Dependence on internal permeant ion concentration.
1976,
Pubmed
Gay,
Cs(+) causes a voltage-dependent block of inward K currents in resting skeletal muscle fibres.
1977,
Pubmed
,
Echinobase
HODGKIN,
The potassium permeability of a giant nerve fibre.
1955,
Pubmed
Hagiwara,
The anomalous rectification and cation selectivity of the membrane of a starfish egg cell.
1974,
Pubmed
,
Echinobase
Hagiwara,
Potassium current and the effect of cesium on this current during anomalous rectification of the egg cell membrane of a starfish.
1976,
Pubmed
,
Echinobase
Hagiwara,
Effects of internal potassium and sodium on the anomalous rectification of the starfish egg as examined by internal perfusion.
1979,
Pubmed
,
Echinobase
Heckmann,
Single file diffusion.
1972,
Pubmed
Hille,
Potassium channels as multi-ion single-file pores.
1978,
Pubmed
Hille,
Ionic selectivity, saturation, and block in sodium channels. A four-barrier model.
1975,
Pubmed
Läuger,
Ion transport through pores: a rate-theory analysis.
1973,
Pubmed
Neher,
Ionic selectivity, saturation, and block in gramicidin A channels. II. Saturation behavior of single channel conductances and evidence for the existence of multiple binding sites in the channel.
1978,
Pubmed
Sandblom,
Ionic selectivity, saturation and block in gramicidin A channels: I. Theory for the electrical properties of ion selective channels having two pairs of binding sites and multiple conductance states.
1977,
Pubmed
Woodhull,
Ionic blockage of sodium channels in nerve.
1973,
Pubmed
