Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-35340
J Nat Prod 1980 Jan 01;432:296-301. doi: 10.1021/np50008a010.
Show Gene links Show Anatomy links

Psorospermin, a new antileukemic xanthone from Psorospermum febrifugum.

Kupchan SM , Streelman DR , Sneden AT .


???displayArticle.abstract???
An ethanolic extract of Psorospermum febrifugum was fractionated with antileukemic activity in vivo in the P388 lymphocytic leukemia in mice and in vitro in the KB cell culture system used as a guide. The new antileukemic xanthone psorospermin 1 was isolated, and its structure was elucidated. The chlorohydrin of O-methylpsorospermin 2 was also isolated after treatment of the fraction containing psorospermin chlorohydrin 6 with diazomethane. Psorospermin 1 was demonstrated to have significant antitumor activity in the P388 in vivo system as well as cytotoxicity against the KB in vitro system.

???displayArticle.pubmedLink??? 7189773
???displayArticle.link??? J Nat Prod


Genes referenced: LOC115919910