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J Gen Physiol
1982 Jan 01;791:115-30. doi: 10.1085/jgp.79.1.115.
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Block of inward rectification by intracellular H+ in immature oocytes of the starfish Mediaster aequalis.
Moody WJ
,
Hagiwara S
.
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Intracellular pH was recorded in immature starfish oocytes using pH-sensitive microelectrodes, and inwardly rectifying potassium currents were measured under voltage clamp. When the intracellular pH was lowered using acetate-buffered artificial sea water from the normal value of 7.09 to 5.9, inward rectification was completely blocked. The relationship between inward rectification and internal pH between 7.09 and 5.9 could be fit by a titration curve for the binding of three H ions to a site with a pK of 6.26 to block the channel. The H+ block showed no voltage dependence, and the activation kinetics of the inwardly rectifying currents were not affected by the changes in internal pH.
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7061984
???displayArticle.pmcLink???PMC2215492 ???displayArticle.link???J Gen Physiol ???displayArticle.grants???[+]
Adrian,
Slow changes in potassium permeability in skeletal muscle.
1970, Pubmed
Adrian,
Slow changes in potassium permeability in skeletal muscle.
1970,
Pubmed
Adrian,
Rectification in muscle membrane.
1969,
Pubmed
Aickin,
An investigation of the ionic mechanism of intracellular pH regulation in mouse soleus muscle fibres.
1977,
Pubmed
Boron,
Intracellular pH transients in squid giant axons caused by CO2, NH3, and metabolic inhibitors.
1976,
Pubmed
Boron,
Intracellular pH transients in giant barnacle muscle fibers.
1977,
Pubmed
Brodwick,
Sodium channel inactivation in squid axon is removed by high internal pH or tyrosine-specific reagents.
1978,
Pubmed
Ciani,
A model for anomalous rectification: electrochemical-potential-dependent gating of membrane channels.
1978,
Pubmed
,
Echinobase
Ellis,
Microelectrode measurement of the intracellular pH of mammalian heart cells.
1976,
Pubmed
GREEN,
The relative rate of penetration of the lower saturated monocarboxylic acids into mammalian erythrocytes.
1949,
Pubmed
Hagiwara,
Blocking effects of barium and hydrogen ions on the potassium current during anomalous rectification in the starfish egg.
1978,
Pubmed
,
Echinobase
Hagiwara,
Voltage clamp analysis of two inward current mechanisms in the egg cell membrane of a starfish.
1975,
Pubmed
,
Echinobase
Hagiwara,
Potassium current and the effect of cesium on this current during anomalous rectification of the egg cell membrane of a starfish.
1976,
Pubmed
,
Echinobase
Jaffe,
Membrane potential of the unfertilized sea urchin egg.
1978,
Pubmed
,
Echinobase
Jaffe,
Fast block to polyspermy in sea urchin eggs is electrically mediated.
1976,
Pubmed
,
Echinobase
Johnson,
Intracellular pH and activation of sea urchin eggs after fertilisation.
1976,
Pubmed
,
Echinobase
Miyazaki,
Potassium rectifications of the starfish oocyte membrane and their changes during oocyte maturation.
1975,
Pubmed
,
Echinobase
Miyazaki,
Fast polyspermy block and activation potential. Correlated changes during oocyte maturation of a starfish.
1979,
Pubmed
,
Echinobase
Miyazaki,
Fast polyspermy block and activation potential. Electrophysiological bases for their changes during oocyte maturation of a starfish.
1979,
Pubmed
,
Echinobase
Moody,
The ionic mechanism of intracellular pH regulation in crayfish neurones.
1981,
Pubmed
Moreau,
Hormonal control of meiosis reinitation in starfish oocytes. New evidence for the absence of efficient intracellular receptors for l-methyladenine recognition.
1978,
Pubmed
,
Echinobase
Nonner,
Low intracellular pH and chemical agents slow inactivation gating in sodium channels of muscle.
1980,
Pubmed
Roos,
Intracellular pH.
1981,
Pubmed
Sharp,
The effects of chloride substitution on intracellular pH in crab muscle.
1981,
Pubmed
Shen,
Direct measurement of intracellular pH during metabolic derepression of the sea urchin egg.
1978,
Pubmed
,
Echinobase
Shen,
Intracellular pH and the sodium requirement at fertilisation.
1979,
Pubmed
,
Echinobase
Standen,
Inward rectification in skeletal muscle: a blocking particle model.
1978,
Pubmed
Thomas,
Intracellular sodium activity and the sodium pump in snail neurones.
1972,
Pubmed
Thomas,
Intracellular pH of snail neurones measured with a new pH-sensitive glass mirco-electrode.
1974,
Pubmed
Wanke,
K+ conductance modified by a titratable group accessible to protons from the intracellular side of the squid axon membrane.
1979,
Pubmed
Woodhull,
Ionic blockage of sodium channels in nerve.
1973,
Pubmed
