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Nucleic Acids Res
1984 Jan 11;121 Pt 1:287-305. doi: 10.1093/nar/12.1part1.287.
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Signal search analysis: a new method to localize and characterize functionally important DNA sequences.
Bucher P
,
Bryan B
.
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The generation of "signal search data" represents a general method of describing the common properties of a set of DNA sequences presumed to be functionally analogous. Besides the detailed description of this method we present two computer programs which use signal search data as input data: One that processes them to a "constraint profile" and another one which lists over-represented "signals" of potential functional relevance. To illustrate the possibilities of our method we have analysed a set of transcription initiation sites of sea urchin histone genes.
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