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ECB-ART-34834
Biochim Biophys Acta 1984 Dec 14;7833:221-6. doi: 10.1016/0167-4781(84)90032-0.
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Inhibition of replicative DNA synthesis in nuclei of Strongylocentrotus intermedium urchin embryo by 2'',3''-dideoxy-3''-aminonucleoside 5''-triphosphates.

Kukhanova M , Krayevsky A , Terentyeva N , Rasskazov V .


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2'',3''-Dideoxy-3''-aminonucleoside 5''-triphosphates have been shown to be inhibitors of replicative DNA synthesis in isolated nuclei of sea urchin embryo. These compounds inhibit the Okazaki fragment synthesis. The effect of 2'',3''-dideoxy-3''-aminothymidine 5''-triphosphate and arabinothymidine 5''-triphosphate is reversible when adding the corresponding substrate for DNA synthesis, 2''-deoxythymidine 5''-triphosphate.

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Genes referenced: LOC100887844