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Nucleic Acids Res
1982 Jul 24;1014:4203-14. doi: 10.1093/nar/10.14.4203.
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Immunoglobulin switch region-like sequences in Drosophila melanogaster.
Sakoyama Y
,
Yaoita Y
,
Honjo T
.
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We found immunoglobulin switch (S) region-like sequences in DNAs of wide variety of organisms including sea urchin, yeast and Drosophila that do not produce immunoglobulins. DNA fragments carrying Smu-like sequences were cloned from Drosophila and the nucleotide sequence of a clone is almost identical to that of the mouse Smu region. Restriction fragments of Drosophila Smu-like sequences and their flanking regions seem to vary among Drosophila species. Possible evolutionary significance of the Smu-like sequence in invertebrates was discussed.
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