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Echinobase
ECB-ART-33681
Science 1970 Oct 23;1703956:447-9. doi: 10.1126/science.170.3956.447.
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Specific inhibition of nuclear RNA polymerase II by alpha-amanitin.

Lindell TJ , Weinberg F , Morris PW , Roeder RG , Rutter WJ .


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alpha-Amanitin, a toxic substance from the mushroom Amanita phalloides, is a potent inhibitor of DNA-dependent RNA polymerase II (the nucleoplasmic form) from sea urchin, rat liver, and calf thymus. This compound exerts no effect on the activity of polymerase I (nucleolar form) or polymerase III (also nucleoplasmic). The inhibition is due to a specific interaction with polymerase II or with a complex of DNA and polymerase II.

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Genes referenced: btaf1 LOC100887844 polr3a