ECB-ART-33681
Science
1970 Oct 23;1703956:447-9. doi: 10.1126/science.170.3956.447.
Show Gene links
Show Anatomy links
Specific inhibition of nuclear RNA polymerase II by alpha-amanitin.
???displayArticle.abstract???
alpha-Amanitin, a toxic substance from the mushroom Amanita phalloides, is a potent inhibitor of DNA-dependent RNA polymerase II (the nucleoplasmic form) from sea urchin, rat liver, and calf thymus. This compound exerts no effect on the activity of polymerase I (nucleolar form) or polymerase III (also nucleoplasmic). The inhibition is due to a specific interaction with polymerase II or with a complex of DNA and polymerase II.
???displayArticle.pubmedLink??? 4918258
???displayArticle.link??? Science
Genes referenced: btaf1 LOC100887844 polr3a