Cell Immunol 1985 Sep 01;942:326-32. doi: 10.1016/0008-8749(85)90256-4.

The cytotoxic reaction of hemocytes from the freshwater crayfish, Astacus astacus.

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Crayfish hemocytes displayed cytotoxic capacity towards all tested mammalian tumor and nontumor cell lines. The ratio required for the cytotoxic action of effector cells to target cells was at least 1:1. The lysis of the target cells required a minimum of 1 hr to become detected. After separation and isolation of the hemocyte populations of crayfish, the semigranular and granular cells retained their cytotoxic capacity. These cells contain the prophenoloxidase activating (proPO) system, a complement-like pathway, which in an activated form lyses semigranular cells in vitro, but failed to kill the tested target cells.

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Genes referenced: LOC100893907 LOC115919910