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Nucleic Acids Res
1988 Aug 11;1615:7487-97. doi: 10.1093/nar/16.15.7487.
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Drosophila has a single copy of the gene encoding a highly conserved histone H2A variant of the H2A.F/Z type.
van Daal A
,
White EM
,
Gorovsky MA
,
Elgin SC
.
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The Tetrahymena histone H2A variant designated hv1 is localized exclusively in the transcriptionally active macronucleus and is absent from the quiescent micronucleus (1). A cDNA clone of the hv1 gene (2) was used to screen a Drosophila cDNA library. A cross-hybridizing clone was recovered and shown by sequence analysis to code for a protein homologous to hv1 as well as to the chicken H2A variant, H2A.F (3), the sea urchin H2A variant, H2A.F/Z (4) and the mammalian H2A variant H2A.Z (5). Southern analysis of Drosophila genomic DNA indicates that the H2AvD (H2A variant Drosophila) gene is present in one copy. In situ hybridization places the locus at 97CD on chromosome 3, while the S-phase regulated histone genes are on chromosome 2 (6). Thus the Drosophila H2A variant should be accessible to genetic analysis, which will enable its function to be determined.
Allis,
hv1 is an evolutionarily conserved H2A variant that is preferentially associated with active genes.
1986, Pubmed
Allis,
hv1 is an evolutionarily conserved H2A variant that is preferentially associated with active genes.
1986,
Pubmed
Allis,
Histone variants specific to the transcriptionally active, amitotically dividing macronucleus of the unicellular eucaryote, Tetrahymena thermophila.
1980,
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Brush,
Replacement variant histone genes contain intervening sequences.
1985,
Pubmed
Ernst,
Characterization of a cDNA clone coding for a sea urchin histone H2A variant related to the H2A.F/Z histone protein in vertebrates.
1987,
Pubmed
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Echinobase
Harvey,
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1983,
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Hatch,
Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged but highly conserved basal histone H2A isoprotein species.
1988,
Pubmed
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Echinobase
Maniatis,
The isolation of structural genes from libraries of eucaryotic DNA.
1978,
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Drosophila nucleosomes contain an unusual histone-like protein.
1980,
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Pardue,
Localization of sequences coding for histone messenger RNA in the chromosomes of Drosophila melanogaster.
1977,
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Echinobase
Poole,
The engrailed locus of Drosophila: structural analysis of an embryonic transcript.
1985,
Pubmed
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Structure of the nucleosome core particle at 7 A resolution.
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Pubmed
Sanger,
DNA sequencing with chain-terminating inhibitors.
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Pubmed
Wells,
Structure of a human histone cDNA: evidence that basally expressed histone genes have intervening sequences and encode polyadenylylated mRNAs.
1985,
Pubmed
White,
Sequence and properties of the message encoding Tetrahymena hv1, a highly evolutionarily conserved histone H2A variant that is associated with active genes.
1988,
Pubmed
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Echinobase
Wu,
Separation of basal histone synthesis from S-phase histone synthesis in dividing cells.
1981,
Pubmed
