Gen Comp Endocrinol 1989 Jul 01;751:1-9. doi: 10.1016/0016-6480(89)90001-4.

Distribution of somatostatin and glucagon immunoreactive cells in the gastric mucosa of some cartilaginous fishes.

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The comparative distribution of somatostatin- and glucagon-like-containing cells in the histomorphologically different gastric mucosae of the cartilaginous fishes Heptranchias perlo, Raja asterias, Scyliorhinus canicula, Squatina aculeata, and Torpedo marmorata was immunocytochemically studied to demonstrate a possible interrelationship between these endocrine cells and/or other endocrine or nonendocrine cells. In the gastric mucosa, these open-type glucagon and somatostatin immunoreactive cells show a double localization with different morphology and interrelationships. At the bottom of gastric pits, which corresponds to a proliferative zone, spindle or pear-shaped immunopositive cells appear rather numerously and are often in close proximity to each other. In gastric glands, triangular or oval immunopositive cells never in contact with each other were detected; their numeric ratio seems to be rather constant even if their numeric frequency and distribution vary according to the histomorphological aspect of selachian gastric glands. Glucagon immunoreactive cells seem to be more related to pepsinogenic cells, while somatostatin immunoreactive cells seem to be more ubiquitous. Both cell types can present basal cytoplasmic processes. From our results we can suggest a possible regulative role exerted by these two peptides on gastric secretion and cell proliferation.

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Genes referenced: LOC115919910