Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
???displayArticle.abstract???
Fertilization of the sea urchin egg triggers a sequence of events that are necessary for metabolic derepression and stimulation of proliferation. Changes in intracellular Ca2+ and H+ activities regulate the sequence of events. Intracellular sodium activity is important in the regulation of the intracellular activities of these ions and may directly regulate metabolic events. Using Na+-sensitive microelectrodes we continuously measured the intracellular Na+ activity during fertilization. The results show an increase in intracellular sodium activity medicated by two pathways of Na+ entry: Na+ permeability increase during the fertilization potential and initiation of Na+-H+ exchange activity. Intracellular Na+ activity returned to unfertilized levels by 20 min after fertilization. This decrease was inhibited by ouabain, which suggests the activation of Na+, K+ ATPase during fertilization.
Benos,
Amiloride: a molecular probe of sodium transport in tissues and cells.
1982, Pubmed
Benos,
Amiloride: a molecular probe of sodium transport in tissues and cells.
1982,
Pubmed
Ciapa,
Sodium-potassium exchange in sea urchin egg. I. Kinetic and biochemical characterization at fertilization.
1984,
Pubmed
,
Echinobase
Ciapa,
Sodium-potassium exchange in sea urchin egg. II. Ionic events stimulating the Na+-K+ pump activity at fertilization.
1984,
Pubmed
,
Echinobase
Cone,
Ionically mediated induction of mitogenesis in CNS neurons.
1980,
Pubmed
Cone,
Unified theory on the basic mechanism of normal mitotic control and oncogenesis.
1971,
Pubmed
Girard,
Changes in intracellular cations following fertilization of sea urchin eggs. Na+/H+ and Na+/K+ exchanges.
1982,
Pubmed
,
Echinobase
Hagiwara,
Electrical properties of egg cell membranes.
1979,
Pubmed
Hülser,
[Stimulation of embryonic rat cells in culture by a protein fraction isolated from fetal calf serum. I. Electrophysiological measurements on cell surface membranes].
1971,
Pubmed
Ito,
Renal activation potential observed in sea urchin egg during fertilization.
1972,
Pubmed
,
Echinobase
Johnson,
Intracellular pH and activation of sea urchin eggs after fertilisation.
1976,
Pubmed
,
Echinobase
Johnson,
Intracellular pH of sea urchin eggs measured by the dimethyloxazolidinedione (DMO) method.
1981,
Pubmed
,
Echinobase
Kaplan,
Membrane cation transport and the control of proliferation of mammalian cells.
1978,
Pubmed
L'Allemain,
Growth factor action and intracellular pH regulation in fibroblasts. Evidence for a major role of the Na+/H+ antiport.
1984,
Pubmed
MARKMAN,
The time sequence of early events in the fertilization of sea urchin eggs. II. The production of acid.
1958,
Pubmed
,
Echinobase
Moolenaar,
Serum triggers a sequence of rapid ionic conductance changes in quiescent neuroblastoma cells.
1979,
Pubmed
Moolenaar,
Rapid ionic events and the initiation of growth in serum-stimulated neuroblastoma cells.
1981,
Pubmed
O'Doherty,
Sodium-selective liquid ion-exchanger microelectrodes for intracellular measurements.
1979,
Pubmed
Paris,
Biochemical characterization of the amiloride-sensitive Na+/H+ antiport in Chinese hamster lung fibroblasts.
1983,
Pubmed
Paul,
Fertilization acid of sea urchin eggs is not a consequence of cortical granule exocytosis.
1976,
Pubmed
,
Echinobase
Paul,
Formation of fertilization acid by sea urchin eggs does not require specific cations.
1975,
Pubmed
,
Echinobase
Payan,
Na+ movements and their oscillations during fertilization and the cell cycle in sea urchin eggs.
1981,
Pubmed
,
Echinobase
Payan,
Mechanisms regulating intracellular pH in sea urchin eggs.
1983,
Pubmed
,
Echinobase
Reuss,
Intracellular ion activities and Cl-transport mechanisms in bullfrog corneal epithelium.
1983,
Pubmed
Rothenberg,
Serum and epidermal growth factor transiently depolarize quiescent BSC-1 epithelial cells.
1982,
Pubmed
Rothenberg,
Activation of Na+/H+ exchange by epidermal growth factor elevates intracellular pH in A431 cells.
1983,
Pubmed
Rozengurt,
Serum rapidly stimulates ouabain-sensitive 86-RB+ influx in quiescent 3T3 cells.
1975,
Pubmed
Rozengurt,
Monovalent ion fluxes and the control of cell proliferation in cultured fibroblasts.
1980,
Pubmed
Schuldiner,
Na+/H+ antiport in Swiss 3T3 cells: mitogenic stimulation leads to cytoplasmic alkalinization.
1982,
Pubmed
Shen,
Intracellular pH controls the development of new potassium conductance after fertilization of the sea urchin egg.
1980,
Pubmed
,
Echinobase
Shen,
Direct measurement of intracellular pH during metabolic derepression of the sea urchin egg.
1978,
Pubmed
,
Echinobase
Shen,
Intracellular pH and the sodium requirement at fertilisation.
1979,
Pubmed
,
Echinobase
Smith,
Serum stimulates the Na+,K+ pump in quiescent fibroblasts by increasing Na+ entry.
1978,
Pubmed
Soltoff,
Amiloride directly inhibits the Na,K-ATPase activity of rabbit kidney proximal tubules.
1983,
Pubmed
Steinhardt,
Bioelectric responses of the echinoderm egg to fertilization.
1971,
Pubmed
,
Echinobase
Steinhardt,
Membrane potential, membrane resistance and an energy requirement for the development of potassium conductance in the fertilization reaction of echinoderm eggs.
1972,
Pubmed
,
Echinobase
Tilney,
Actin, microvilli, and the fertilization cone of sea urchin eggs.
1980,
Pubmed
,
Echinobase
Whitaker,
Ionic regulation of egg activation.
1982,
Pubmed
,
Echinobase
