ECB-ART-31547
Prostaglandins
1990 Jun 01;396:611-22. doi: 10.1016/0090-6980(90)90022-n.
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Levuglandin E2 inhibits mitosis and microtubule assembly.
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Levuglandin E2 (LGE2) is a gamma-keto aldehyde produced by rearrangement of the prostaglandin endoperoxide PGH2 under the aqueous conditions of its biosynthesis. We show that exogenous LGE2 enters cells and efficiently inhibits the first synchronous cell division of fertilized sea urchin eggs. We attribute this inhibition to covalent modification of tubulin and thereby to inhibition of microtubule assembly.
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Genes referenced: LOC100887844 LOC115919910 tubgcp2