ECB-ART-31541
Braz J Med Biol Res
1990 Jan 01;239:811-4.
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Antimitotic effect of an extract of the sea anemone Bunodosoma caissarum on sea urchin egg development.
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A methanolic extract of the sea anemone Bunodosoma caissarum has an antimitotic effect on sea urchin egg development. The extract produces a dose-dependent inhibition of cell cleavage. When the extract is added together with sperm to unfertilized sea urchin eggs, the ED50 is 0.60 +/- 0.03 mg/ml (mean +/- SEM). When added shortly after fertilization, the extract produces the same kind of progressive inhibition but with an ED50 of 0.98 +/- 0.16 mg/ml. In the first case, detachment of the vitelline layer is inhibited whereas in the second case the extract inhibits cleavage even when the membrane is present.
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Genes referenced: LOC100887844 LOC115919910