Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
A novel class of plant proteins containing a homeodomain with a closely linked leucine zipper motif.
Ruberti I
,
Sessa G
,
Lucchetti S
,
Morelli G
.
???displayArticle.abstract???
The homeobox, a 183 bp DNA sequence element, was originally identified as a region of sequence similarity between many Drosophila homeotic genes. The homeobox codes for a DNA-binding motif known as the homeodomain. Homeobox genes have been found in many animal species, including sea urchins, nematodes, frogs, mice and humans. To isolate homeobox-containing sequences from the plant Arabidopsis thaliana, a cDNA library was screened with a highly degenerate oligonucleotide corresponding to a conserved eight amino acid sequence from the helix-3 region of the homeodomain. Using this strategy two cDNA clones sharing homeobox-related sequences were identified. Interestingly, both of the cDNAs also contain a second element that potentially codes for a leucine zipper motif which is located immediately 3'' to the homeobox. The close proximity of these two domains suggests that the homeodomain-leucine zipper motif could, via dimerization of the leucine zippers, recognize dyad-symmetrical DNA sequences.
Affolter,
Homeodomain proteins and the regulation of gene expression.
1990, Pubmed
Affolter,
Homeodomain proteins and the regulation of gene expression.
1990,
Pubmed
Bürglin,
Caenorhabditis elegans has scores of homoeobox-containing genes.
1989,
Pubmed
Bürglin,
The yeast regulatory gene PHO2 encodes a homeo box.
1988,
Pubmed
Carrasco,
Cloning of an X. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes.
1984,
Pubmed
Devereux,
A comprehensive set of sequence analysis programs for the VAX.
1984,
Pubmed
Feinberg,
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
1983,
Pubmed
Frigerio,
Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network.
1986,
Pubmed
Gehring,
Homeo boxes in the study of development.
1987,
Pubmed
Gehring,
The structure of the homeodomain and its functional implications.
1990,
Pubmed
Harding,
Cross-regulatory interactions among pair-rule genes in Drosophila.
1986,
Pubmed
Hart,
Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: evolutionary and structural comparisons.
1987,
Pubmed
Hartings,
The O2 gene which regulates zein deposition in maize endosperm encodes a protein with structural homologies to transcriptional activators.
1989,
Pubmed
Hayashi,
What determines the specificity of action of Drosophila homeodomain proteins?
1990,
Pubmed
Hinnebusch,
Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae.
1988,
Pubmed
Hinnebusch,
Evidence for translational regulation of the activator of general amino acid control in yeast.
1984,
Pubmed
Hoey,
Homeo box gene expression in anterior and posterior regions of the Drosophila embryo.
1986,
Pubmed
Hoey,
DNA-binding activities of the Drosophila melanogaster even-skipped protein are mediated by its homeo domain and influenced by protein context.
1988,
Pubmed
Hu,
Sequence requirements for coiled-coils: analysis with lambda repressor-GCN4 leucine zipper fusions.
1990,
Pubmed
Johnson,
Eukaryotic transcriptional regulatory proteins.
1989,
Pubmed
Katagiri,
Two tobacco DNA-binding proteins with homology to the nuclear factor CREB.
1989,
Pubmed
Keleher,
The yeast cell-type-specific repressor alpha 2 acts cooperatively with a non-cell-type-specific protein.
1988,
Pubmed
Kissinger,
Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: a framework for understanding homeodomain-DNA interactions.
1990,
Pubmed
Lam,
A metal-dependent DNA-binding protein interacts with a constitutive element of a light-responsive promoter.
1990,
Pubmed
Landschulz,
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.
1988,
Pubmed
Laughon,
Common properties of proteins encoded by the Antennapedia complex genes of Drosophila melanogaster.
1985,
Pubmed
Laughon,
Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins.
1984,
Pubmed
Ludwig,
Maize R gene family: tissue-specific helix-loop-helix proteins.
1990,
Pubmed
McGinnis,
Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila.
1984,
Pubmed
Miller,
Identification and comparison of two sequence elements that confer cell-type specific transcription in yeast.
1985,
Pubmed
Nasmyth,
A position effect in the control of transcription at yeast mating type loci.
1981,
Pubmed
Nicosia,
A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1.
1990,
Pubmed
Otting,
Protein--DNA contacts in the structure of a homeodomain--DNA complex determined by nuclear magnetic resonance spectroscopy in solution.
1990,
Pubmed
Poole,
The engrailed locus of Drosophila: structural analysis of an embryonic transcript.
1985,
Pubmed
Ptashne,
How eukaryotic transcriptional activators work.
1988,
Pubmed
Qian,
The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: comparison with prokaryotic repressors.
1989,
Pubmed
Regulski,
Homeo box genes of the Antennapedia and bithorax complexes of Drosophila.
1985,
Pubmed
Scheidereit,
A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein.
1988,
Pubmed
Schulz,
The b alleles of U. maydis, whose combinations program pathogenic development, code for polypeptides containing a homeodomain-related motif.
1990,
Pubmed
Scott,
The structure and function of the homeodomain.
1989,
Pubmed
Shepherd,
Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins.
1984,
Pubmed
Singh,
OCSBF-1, a maize ocs enhancer binding factor: isolation and expression during development.
1990,
Pubmed
Thomas,
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
1980,
Pubmed
Vinson,
Scissors-grip model for DNA recognition by a family of leucine zipper proteins.
1989,
Pubmed
