Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Proc Natl Acad Sci U S A
1979 Apr 01;764:1916-20. doi: 10.1073/pnas.76.4.1916.
Show Gene links
Show Anatomy links
Biochemical and electron microscopic evidence that cell nucleus negatively controls mitochondrial genomic activity in early sea urchin development.
Rinaldi AM
,
De Leo G
,
Arzone A
,
Salcher I
,
Storace A
,
Mutolo V
.
???displayArticle.abstract???
Enucleated halves of sea urchin eggs obtained by centrifugation contain almost all the mitochondrial population of the egg. Removal of the nucleus followed by parthenogenetic activation stimulates the incorporation of [3H]thymidine into the mitochondrial DNA, whereas no such incorportion is observed in activated whole eggs. The block is not the result of a modification in the permeability of the mitochondrial membrane. Electron microscopic observations demonstrated duplication of mitochondrial DNA molecules in activated enucleated halves. No duplication was found in the mitochondrial DNA from activated whole eggs or from nonactivated enucleated halves. We conclude that the cell nucleus exerts a negative control on the activity of the mitochondrial genome through some short-lived nuclear substance(s).
Chamberlain,
RNA synthesis in anucleate egg fragments and normal embryos of the sea urchin, Arbacia punctulata.
1970, Pubmed,
Echinobase
Chamberlain,
RNA synthesis in anucleate egg fragments and normal embryos of the sea urchin, Arbacia punctulata.
1970,
Pubmed
,
Echinobase
Chamberlain,
Mitochondrial RNA synthesis in sea urchin embryos.
1972,
Pubmed
,
Echinobase
Craig,
Protein synthesis and development in the absence of cytoplasmic RNA synthesis in nonnucleate egg fragments and embryos of sea urchins: effect of ethidium bromide.
1971,
Pubmed
,
Echinobase
Craig,
Synthesis of RNA in non-nucleate fragments of sea urchin eggs.
1970,
Pubmed
,
Echinobase
Epel,
An analysis of the partial metabolic derepression of sea urchin eggs by ammonia: the existence of independent pathways.
1974,
Pubmed
,
Echinobase
Giudice,
Synthesis of ribosomal RNA during sea-urchin development.
1967,
Pubmed
,
Echinobase
Hartmann,
Sea urchin embryogenesis. I. RNA synthesis by cytoplasmic and nuclear genes during development.
1971,
Pubmed
,
Echinobase
Hartmann,
Transcription of nuclear and cytoplasmic genes during early development of sea urchin embryos.
1969,
Pubmed
,
Echinobase
Matsumoto,
Mitochondrial DNA replication in sea urchin oocytes.
1974,
Pubmed
,
Echinobase
REYNOLDS,
The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.
1963,
Pubmed
Rinaldi,
Cell nucleus negatively controls mitochondrial RNA synthesis in early sea urchin development.
1977,
Pubmed
,
Echinobase
Selvig,
Cytoplasmic synthesis of RNA in the sea urchin embryo.
1970,
Pubmed
,
Echinobase
Selvig,
Cytoplasmic synthesis of RNA in the sea urchin embryo. II. Mitochondrial transcription.
1972,
Pubmed
,
Echinobase
Wilt,
Polyadenylation of maternal RNA of sea urchin eggs after fertilization.
1973,
Pubmed
,
Echinobase
