ECB-ART-42931
Wiley Interdiscip Rev Dev Biol
2012 Jan 01;12:231-52. doi: 10.1002/wdev.18.
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Morphogenesis in sea urchin embryos: linking cellular events to gene regulatory network states.
Lyons DC
,
Kaltenbach SL
,
McClay DR
.
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Gastrulation in the sea urchin begins with ingression of the primary mesenchyme cells (PMCs) at the vegetal pole of the embryo. After entering the blastocoel the PMCs migrate, form a syncitium, and synthesize the skeleton of the embryo. Several hours after the PMCs ingress the vegetal plate buckles to initiate invagination of the archenteron. That morphogenetic process occurs in several steps. The nonskeletogenic cells produce the initial inbending of the vegetal plate. Endoderm cells then rearrange and extend the length of the gut across the blastocoel to a target near the animal pole. Finally, cells that will form part of the midgut and hindgut are added to complete gastrulation. Later, the stomodeum invaginates from the oral ectoderm and fuses with the foregut to complete the archenteron. In advance of, and during these morphogenetic events, an increasingly complex input of transcription factors controls the specification and the cell biological events that conduct the gastrulation movements.
???displayArticle.pubmedLink??? 23801438
???displayArticle.pmcLink??? PMC3744329
???displayArticle.link??? Wiley Interdiscip Rev Dev Biol
???displayArticle.grants??? [+]
P01 HD037105 NICHD NIH HHS , HD 37105 NICHD NIH HHS , GM 81883 NIGMS NIH HHS , HD 14483 NICHD NIH HHS , R01 HD014483 NICHD NIH HHS
Genes referenced: LOC100887844 LOC115919910 pole
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