ECB-ART-41517
Wiley Interdiscip Rev Syst Biol Med
2009 Jan 01;12:237-246. doi: 10.1002/wsbm.24.
Experimentally based sea urchin gene regulatory network and the causal explanation of developmental phenomenology.
Ben-Tabou de-Leon S
,
Davidson EH
.
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Gene regulatory networks for development underlie cell fate specification and differentiation. Network topology, logic and dynamics can be obtained by thorough experimental analysis. Our understanding of the gene regulatory network controlling
endomesoderm specification in the sea urchin
embryo has attained an advanced level such that it explains developmental phenomenology. Here we review how the network explains the mechanisms utilized in development to control the formation of dynamic expression patterns of transcription factors and signaling molecules. The network represents the genomic program controlling timely activation of specification and differentiation genes in the correct embryonic lineages. It can also be used to study evolution of body plans. We demonstrate how comparing the sea urchin gene regulatory network to that of the sea star and to that of later developmental stages in the sea urchin, reveals mechanisms underlying the origin of evolutionary novelty. The experimentally based gene regulatory network for
endomesoderm specification in the sea urchin
embryo provides unique insights into the system level properties of cell fate specification and its evolution.
???displayArticle.pubmedLink???
20228891
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PMC2836836
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Wiley Interdiscip Rev Syst Biol Med
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[+]
Genes referenced:
LOC100887844
LOC115919910
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