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Sea Cucumber Peptide Alleviates Ulcerative Colitis Induced by Dextran Sulfate Sodium by Alleviating Gut Microbiota Imbalance and Regulating miR-155/SOCS1 Axis in Mice.
Mao J
,
Zhao Y
,
Wang L
,
Wu T
,
Jin Y
,
Meng J
,
Zhang M
.
Abstract
Sea cucumber peptides have been proven to exhibit a variety of biological activities. Ulcerative colitis (UC) is a chronic disease characterized by diffuse inflammation of the mucosa of the rectum and colon with increasing incidence and long duration, and is difficult to cure. The effect of sea cucumber peptide on UC is currently unknown. In this study, 1.5% dextran sulfate sodium (DSS) was added to the drinking water of mice to induce a UC model, and the daily doses of sea cucumber peptide (SP) solution of 200 mg/kg·BW, 500 mg/kg·BW, and 1000 mg/kg·BW were given to UC mice to detect the relieving effect of SP. The results showed that SP can reduce the disease activity index (DAI) of UC mice induced by DSS and can alleviate colon shortening, intestinal tissue damage, and the loss of intestinal tight junction proteins (Claudin-1, Occludin). SP decreased the spleen index, pro-inflammatory factors (IL-1β, IL-6, TNF-α), and myeloperoxidase (MPO) levels in UC mice. SP can alleviate the imbalance of gut microbiota in UC mice, increase the abundance of the Lachnospiraceae NK4A136 group, Prevotellaceae UCG-001, and Ligilactobacillus, and reduce the abundance of Bacteroides and the Eubacterium rum group, as well as alleviating the decrease in short-chain fatty acid (SCFA) content in the feces of UC mice. Notably, SP inhibited miR-155 expression in the colon tissue of UC mice and increased its target protein, suppressor of cytokine signaling 1 (SOCS1), which acts as an inflammatory inhibitor. In summary, the ameliorative effect of SP on UC may be achieved by improving the imbalance of gut microbiota and regulating the miR-155/SOCS1 axis. This study provides a new idea for developing SP as a nutritional supplement to maintain intestinal health.
2022YFF1100201 National Key R&D Program of China, 201926 Tianjin "131" Innovative Talent Team Project, 81902441, 82072709 National Natural Science Foundation of China, 2022M712374 China Postdoctoral Science Foundation
Alivernini,
MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis.
2017, Pubmed
Alivernini,
MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis.
2017,
Pubmed
Bao,
Impact of food-derived bioactive peptides on gut function and health.
2021,
Pubmed
Baumgart,
Inflammatory bowel disease: clinical aspects and established and evolving therapies.
2007,
Pubmed
Bordbar,
High-value components and bioactives from sea cucumbers for functional foods--a review.
2011,
Pubmed
,
Echinobase
Cosnes,
Epidemiology and natural history of inflammatory bowel diseases.
2011,
Pubmed
Croker,
SOCS regulation of the JAK/STAT signalling pathway.
2008,
Pubmed
De Vadder,
Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits.
2014,
Pubmed
Durchschein,
Diet therapy for inflammatory bowel diseases: The established and the new.
2016,
Pubmed
Fan,
The in vitro and in vivo anti-inflammatory effect of osthole, the major natural coumarin from Cnidium monnieri (L.) Cuss, via the blocking of the activation of the NF-κB and MAPK/p38 pathways.
2019,
Pubmed
Feng,
Major yolk protein from sea cucumber (Stichopus japonicus) attenuates acute colitis via regulation of microbial dysbiosis and inflammatory responses.
2022,
Pubmed
,
Echinobase
Filipowicz,
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
2008,
Pubmed
Gao,
Butyrate improves insulin sensitivity and increases energy expenditure in mice.
2009,
Pubmed
Ge,
Egg white peptides ameliorate dextran sulfate sodium-induced acute colitis symptoms by inhibiting the production of pro-inflammatory cytokines and modulation of gut microbiota composition.
2021,
Pubmed
Hering,
Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics.
2012,
Pubmed
Hu,
Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.
2021,
Pubmed
Huang,
Ripened Pu-erh Tea Extract Promotes Gut Microbiota Resilience against Dextran Sulfate Sodium Induced Colitis.
2021,
Pubmed
Li,
Potential Mechanisms Mediating the Protective Effects of Tricholoma matsutake-Derived Peptides in Mitigating DSS-Induced Colitis.
2021,
Pubmed
Li,
MiR-155 promotes colitis-associated intestinal fibrosis by targeting HBP1/Wnt/β-catenin signalling pathway.
2021,
Pubmed
Lu,
Production of Bioactive Peptides from Sea Cucumber and Its Potential Health Benefits: A Comprehensive Review.
2022,
Pubmed
,
Echinobase
McKenzie,
Splenomegaly: Pathophysiological bases and therapeutic options.
2018,
Pubmed
Neurath,
Targeting immune cell circuits and trafficking in inflammatory bowel disease.
2019,
Pubmed
Ng,
Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.
2017,
Pubmed
Pang,
Vitamin A supplementation ameliorates ulcerative colitis in gut microbiota-dependent manner.
2021,
Pubmed
Pathak,
MiR-155 modulates the inflammatory phenotype of intestinal myofibroblasts by targeting SOCS1 in ulcerative colitis.
2015,
Pubmed
Peng,
Gut microbiota modulation and anti-inflammatory properties of anthocyanins from the fruits of Lycium ruthenicum Murray in dextran sodium sulfate-induced colitis in mice.
2019,
Pubmed
Shen,
Dietary supplementation of gingerols- and shogaols-enriched ginger root extract attenuate pain-associated behaviors while modulating gut microbiota and metabolites in rats with spinal nerve ligation.
2022,
Pubmed
Shin,
Proteobacteria: microbial signature of dysbiosis in gut microbiota.
2015,
Pubmed
Shinoda,
Early-stage blocking of Notch signaling inhibits the depletion of goblet cells in dextran sodium sulfate-induced colitis in mice.
2010,
Pubmed
Singh,
miR-155 deficiency protects mice from experimental colitis by reducing T helper type 1/type 17 responses.
2014,
Pubmed
Su,
Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis.
2009,
Pubmed
Vacca,
The Controversial Role of Human Gut Lachnospiraceae.
2020,
Pubmed
Vigorito,
miR-155: an ancient regulator of the immune system.
2013,
Pubmed
Wan,
Caffeic Acid Supplement Alleviates Colonic Inflammation and Oxidative Stress Potentially Through Improved Gut Microbiota Community in Mice.
2021,
Pubmed
Wang,
Ameliorative effects of L-theanine on dextran sulfate sodium induced colitis in C57BL/6J mice are associated with the inhibition of inflammatory responses and attenuation of intestinal barrier disruption.
2020,
Pubmed
Wen,
Chemical composition and nutritional quality of sea cucumbers.
2010,
Pubmed
,
Echinobase
Wirtz,
Chemically induced mouse models of acute and chronic intestinal inflammation.
2017,
Pubmed
Xue,
The effects of live and pasteurized Akkermansia muciniphila on DSS-induced ulcerative colitis, gut microbiota, and metabolomics in mice.
2023,
Pubmed
Yamashita,
Improvement of obesity and glucose tolerance by acetate in Type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
2007,
Pubmed
Yoshimura,
SOCS, Inflammation, and Autoimmunity.
2012,
Pubmed
Zeng,
An engineering probiotic producing defensin-5 ameliorating dextran sodium sulfate-induced mice colitis via Inhibiting NF-kB pathway.
2020,
Pubmed
Zhao,
Sesamol Supplementation Attenuates DSS-Induced Colitis via Mediating Gut Barrier Integrity, Inflammatory Responses, and Reshaping Gut Microbiome.
2020,
Pubmed
da Silva,
Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis.
2014,
Pubmed
