Rocha J et al. (2011), Cnidarians as a source of new marine bioactive ...

ECB-ART-42232

Mar Drugs 2011 Jan 01;910:1860-1886. doi: 10.3390/md9101860.

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Cnidarians as a source of new marine bioactive compounds--an overview of the last decade and future steps for bioprospecting.

Rocha J , Peixe L , Gomes NCM , Calado R .

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Marine invertebrates are rich sources of bioactive compounds and their biotechnological potential attracts scientific and economic interest worldwide. Although sponges are the foremost providers of marine bioactive compounds, cnidarians are also being studied with promising results. This diverse group of marine invertebrates includes over 11,000 species, 7500 of them belonging to the class Anthozoa. We present an overview of some of the most promising marine bioactive compounds from a therapeutic point of view isolated from cnidarians in the first decade of the 21st century. Anthozoan orders Alcyonacea and Gorgonacea exhibit by far the highest number of species yielding promising compounds. Antitumor activity has been the major area of interest in the screening of cnidarian compounds, the most promising ones being terpenoids (monoterpenoids, diterpenoids, sesquiterpenoids). We also discuss the future of bioprospecting for new marine bioactive compounds produced by cnidarians.

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References [+] :

Aceret, Cardiac and vascular responses of isolated rat tissues treated with diterpenes from Sinularia flexibilis (coelenterata: octocorallia). 1996, Pubmed

	Figure 1. Some cnidarians addressed in this review (all images by Ricardo Calado). (A) Sinularia sp.; (B) Xenia sp.; (C) Sarcophyton sp.; (D) Briareum sp.
	Figure 2. Marine bioactive compounds with high biotechnological potential studied from the phylum Cnidaria in the last decade.
	Figure 3. Distribution in drug classes of marine bioactive compounds with high biotechnological potential studied from cnidarian species in the last decade.
	Figure 4. Distribution of chemistry classes of marine bioactive compounds with high biotechnological potential studied from cnidarian species in the last decade.