Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-48431
Drug Discov Today 2019 Feb 01;242:533-543. doi: 10.1016/j.drudis.2018.10.015.
Show Gene links Show Anatomy links

Microtransplantation of human brain receptors into oocytes to tackle key questions in drug discovery.

Zwart R , Mazzo F , Sher E .


Abstract
It is important in drug discovery to demonstrate that activity of novel drugs found by screening on recombinant receptors translates to activity on native human receptors in brain areas affected by disease. In this review, we summarise the development and use of the microtransplantation technique. Native receptors are reconstituted from human brain tissues into oocytes from the frog Xenopus laevis where they can be functionally assessed. Oocytes microtransplanted with hippocampal tissue from an epileptic patient were used to demonstrate that new antiepileptic agents act on receptors in diseased tissue. Furthermore, frozen post-mortem human tissues were used to show that drugs are active on receptors in brain areas associated with a disease; but not in areas associated with side effects.

PubMed ID: 30395928
Article link: Drug Discov Today


Genes referenced: LOC590297