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SpCoel1: a sea urchin profilin gene expressed specifically in coelomocytes in response to injury.
Smith LC
,
Britten RJ
,
Davidson EH
.
???displayArticle.abstract??? SpCoel1 is a single copy gene that is specifically expressed in most of the coelomocytes of the adult purple sea urchin, Strongylocentrotus purpuratus. The 4-kb transcript from this gene has a relatively short (426 nucleotide) open reading frame (ORF) with long 3'' and 5'' untranslated regions. The ORF encodes a protein that has strong amino acid sequence similarity to profilins from yeast to mammals. Transcript titrations of SpCoel1 show significant increases per coelomocyte in animals that have been physiologically challenged. Increases in transcript levels are of similar magnitudes between animals receiving different treatments, such as injuries from needle punctures or from injections of foreign cells. The evidence presented here implies a molecular mechanism by which this lower deuterostome defense system responds to external insult, viz that an external "injury signal" activates a signal transduction system, which in turn mediates the alterations in cytoskeletal state that are required for coelomocyte activation.
Ampe,
The primary structure of human platelet profilin: reinvestigation of the calf spleen profilin sequence.
1988, Pubmed
Ampe,
The primary structure of human platelet profilin: reinvestigation of the calf spleen profilin sequence.
1988,
Pubmed
Ampe,
The primary structure of the basic isoform of Acanthamoeba profilin.
1988,
Pubmed
Ampe,
The amino acid sequence of Acanthamoeba profilin.
1985,
Pubmed
Bertheussen,
Endocytosis by echinoid phagocytosis in vitro. I. Recognition of foreign matter.
1981,
Pubmed
,
Echinobase
Bertheussen,
The cytotoxic reaction in allogeneic mixtures of echinoid phagocytes.
1979,
Pubmed
,
Echinobase
Binette,
Cell-specific expression of a profilin gene family.
1990,
Pubmed
Cameron,
Expression of two actin genes during larval development in the sea urchin Strongylocentrotus purpuratus.
1989,
Pubmed
,
Echinobase
Chen,
NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.
1990,
Pubmed
Coffaro,
Immune response in the sea urchin Lytechinus pictus.
1977,
Pubmed
,
Echinobase
Edds,
Coelomocyte motility.
1983,
Pubmed
,
Echinobase
Edds,
The formation and elongation of filopodia during transformation of sea urchin coelomocytes.
1980,
Pubmed
,
Echinobase
Edds,
Dynamic aspects of filopodial formation by reorganization of microfilaments.
1977,
Pubmed
,
Echinobase
Goldschmidt-Clermont,
Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation.
1991,
Pubmed
Goldschmidt-Clermont,
The actin-binding protein profilin binds to PIP2 and inhibits its hydrolysis by phospholipase C.
1990,
Pubmed
Goldschmidt-Clermont,
Mechanism of the interaction of human platelet profilin with actin.
1991,
Pubmed
Goustin,
Protein synthesis, polyribosomes, and peptide elongation in early development of Strongylocentrotus purpuratus.
1981,
Pubmed
,
Echinobase
HUMPHREYS,
CHEMICAL DISSOLUTION AND IN VITRO RECONSTRUCTION OF SPONGE CELL ADHESIONS. I. ISOLATION AND FUNCTIONAL DEMONSTRATION OF THE COMPONENTS INVOLVED.
1963,
Pubmed
Haarer,
Structure and function of profilin.
1990,
Pubmed
Johnson,
The coelomic elements of sea urchins (Strongylocentrotus). 3. In vitro reaction to bacteria.
1969,
Pubmed
,
Echinobase
Kwiatkowski,
Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis.
1988,
Pubmed
Lassing,
Specificity of the interaction between phosphatidylinositol 4,5-bisphosphate and the profilin:actin complex.
1988,
Pubmed
Lassing,
Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin.
1985,
Pubmed
Leahy,
Laboratory culture of Strongylocentrotus purpuratus adults, embryos, and larvae.
1986,
Pubmed
,
Echinobase
Leahy,
A large-scale laboratory maintenance system for gravid purple sea urchins (Strongylocentrotus purpuratus).
1978,
Pubmed
,
Echinobase
Lee,
Activation of sea urchin actin genes during embryogenesis. Measurement of transcript accumulation from five different genes in Strongylocentrotus purpuratus.
1986,
Pubmed
,
Echinobase
Machesky,
The affinities of human platelet and Acanthamoeba profilin isoforms for polyphosphoinositides account for their relative abilities to inhibit phospholipase C.
1990,
Pubmed
Messing,
A system for shotgun DNA sequencing.
1981,
Pubmed
Oechsner,
The cDNA and deduced amino acid sequence of profilin from Saccharomyces cerevisiae.
1987,
Pubmed
Pearson,
Improved tools for biological sequence comparison.
1988,
Pubmed
Pollard,
Analysis of cDNA clones for Acanthamoeba profilin-I and profilin-II shows end to end homology with vertebrate profilins and a small family of profilin genes.
1991,
Pubmed
Reichstein,
Acanthamoeba profilin. A protein of low molecular weight from Acanpthamoeba castellanii that inhibits actin nucleation.
1979,
Pubmed
Reinisch,
Cell recognition: reactions of the sea star (Asterias vulgaris) to the injection of amebocytes of sea urchin (Arbacia punctulata).
1971,
Pubmed
,
Echinobase
Rothenberg,
IL-2 gene inducibility in T cells before T cell receptor expression. Changes in signaling pathways and gene expression requirements during intrathymic maturation.
1990,
Pubmed
Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed
Schuler,
A workbench for multiple alignment construction and analysis.
1991,
Pubmed
Stossel,
From signal to pseudopod. How cells control cytoplasmic actin assembly.
1989,
Pubmed
Studier,
Use of T7 RNA polymerase to direct expression of cloned genes.
1990,
Pubmed
Takagi,
Primary structure of profilins from two species of Echinoidea and Physarum polycephalum.
1990,
Pubmed
,
Echinobase
Vojtek,
Evidence for a functional link between profilin and CAP in the yeast S. cerevisiae.
1991,
Pubmed
Widada,
Total coding sequence of profilin cDNA from Mus musculus macrophage.
1989,
Pubmed
Yamamoto,
The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA.
1984,
Pubmed
Yamamoto,
Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit.
1986,
Pubmed