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Proc Natl Acad Sci U S A
1993 Dec 01;9023:11132-6. doi: 10.1073/pnas.90.23.11132.
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A fertility region on the Y chromosome of Drosophila melanogaster encodes a dyneinmicrotubule motor.
Gepner J
,
Hays TS
.
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A clone encoding a portion of the highly conserved ATP-binding domain of a dynein heavy-chain polypeptide was mapped to a region of the Drosophila melanogaster Y chromosome. Dyneins are large multisubunit enzymes that utilize the hydrolysis of ATP to move along microtubules. They were first identified as the motors that provide the force for flagellar and ciliary bending. Seven different dynein heavy-chain genes have been identified in D. melanogaster by PCR. In the present study, we demonstrate that one of the dynein genes, Dhc-Yh3, is located in Y chromosome region h3, which is contained within kl-5, a locus required for male fertility. The PCR clone derived from Dhc-Yh3 is 85% identical to the corresponding region of the beta heavy chain of sea urchin flagellar dynein but only 53% identical to a cytoplasmic dynein heavy chain from Drosophila. In situ hybridization to Drosophila testes shows Dhc-Yh3 is expressed in wild-type males but not in males missing the kl-5 region. These results are consistent with the hypothesis that the Y chromosome is needed for male fertility because it contains conventional genes that function during spermiogenesis.
Ayles,
Temperature-sensitive mutations in Drosophila melanogaster. XI. Male sterile mutants of the Y chromosome.
1973, Pubmed
Ayles,
Temperature-sensitive mutations in Drosophila melanogaster. XI. Male sterile mutants of the Y chromosome.
1973,
Pubmed
Bonaccorsi,
Y chromosome loops in Drosophila melanogaster.
1988,
Pubmed
Bonaccorsi,
Fine mapping of satellite DNA sequences along the Y chromosome of Drosophila melanogaster: relationships between satellite sequences and fertility factors.
1991,
Pubmed
Bonaccorsi,
Transcription of a satellite DNA on two Y chromosome loops of Drosophila melanogaster.
1990,
Pubmed
Bridges,
Non-Disjunction as Proof of the Chromosome Theory of Heredity (Concluded).
1916,
Pubmed
Brosseau,
Genetic Analysis of the Male Fertility Factors on the Y Chromosome of Drosophila Melanogaster.
1960,
Pubmed
Eberl,
The role of heterochromatin in the expression of a heterochromatic gene, the rolled locus of Drosophila melanogaster.
1993,
Pubmed
Gatti,
Functional elements in Drosophila melanogaster heterochromatin.
1992,
Pubmed
Gibbons,
Multiple nucleotide-binding sites in the sequence of dynein beta heavy chain.
1991,
Pubmed
,
Echinobase
Goldstein,
Structural genes on the Y chromosome of Drosophila melanogaster.
1982,
Pubmed
Gowen,
Gene Number, Kind, and Size in Drosophila.
1933,
Pubmed
Hackstein,
Genetic and cytogenetic analysis of the "Th-Ps" region of the Y chromosome of Drosophila hydei: evidence for dual functions of the lampbrush loop-forming fertility genes?
1991,
Pubmed
Hardy,
The influence of chromosome content on the size and shape of sperm heads in Drosophila melanogaster and the demonstration of chromosome loss during spermiogenesis.
1975,
Pubmed
Hardy,
Analysis of spermatogenesis in Drosophila melanogaster bearing deletions for Y-chromosome fertility genes.
1981,
Pubmed
Hardy,
Cytogenetic analysis of a segment of the Y chromosome of Drosophila melanogaster.
1984,
Pubmed
Hilliker,
Genetic analysis of the centromeric heterochromatin of chromosome 2 of Drosophila melanogaster: deficiency mapping of EMS-induced lethal complementation groups.
1976,
Pubmed
Kennison,
The Genetic and Cytological Organization of the Y Chromosome of DROSOPHILA MELANOGASTER.
1981,
Pubmed
Kennison,
Analysis of Y-Linked Mutations to Male Sterility in DROSOPHILA MELANOGASTER.
1983,
Pubmed
Kiefer,
Ultrastructural Abnormalities in Developing Sperm of X/0 DROSOPHILA MELANOGASTER.
1966,
Pubmed
Koonce,
Dynein from Dictyostelium: primary structure comparisons between a cytoplasmic motor enzyme and flagellar dynein.
1992,
Pubmed
,
Echinobase
Lindsley,
Segmental aneuploidy and the genetic gross structure of the Drosophila genome.
1972,
Pubmed
Livak,
Detailed structure of the Drosophila melanogaster stellate genes and their transcripts.
1990,
Pubmed
Marchant,
Genetic Analysis of the Heterochromatin of Chromosome 3 in Drosophila Melanogaster. II. Vital Loci Identified through Ems Mutagenesis.
1988,
Pubmed
Marsh,
Is sex determination in germ line and soma controlled by separate genetic mechanisms?
1978,
Pubmed
Mikami,
Molecular cloning of the retrograde transport motor cytoplasmic dynein (MAP 1C).
1993,
Pubmed
,
Echinobase
Ogawa,
Four ATP-binding sites in the midregion of the beta heavy chain of dynein.
1991,
Pubmed
,
Echinobase
Pisano,
The kl-3 loop of the Y chromosome of Drosophila melanogaster binds a tektin-like protein.
1993,
Pubmed
Porter,
Dynein structure and function.
1989,
Pubmed
RITOSSA,
LOCALIZATION OF DNA COMPLEMENTARY TO RIBOSOMAL RNA IN THE NUCLEOLUS ORGANIZER REGION OF DROSOPHILA MELANOGASTER.
1965,
Pubmed
Tautz,
A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback.
1989,
Pubmed
Williamson,
Ethyl methanesulfonate-induced mutants in the Y chromosome of Drosophila melanogaster.
1970,
Pubmed
Williamson,
Allelic complementation between mutants in the fertility factyors of the Y chromosome in Drosophila melanogaster.
1972,
Pubmed
