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ECB-ART-45691
Front Chem 2017 Jan 01;5:54. doi: 10.3389/fchem.2017.00054.
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Analysis of Urine Composition in Type II Diabetic Mice after Intervention Therapy Using Holothurian Polypeptides.

Li Y , Xu J , Su X .


Abstract
Hydrolysates and peptide fractions (PF) obtained from sea cucumber with commercial enzyme were studied on the hyperglycemic and renal protective effects on db/db rats using urine metabolomics. Compared with the control group the polypeptides from the two species could significantly reduce the urine glucose and urea. We also tried to address the compositions of highly expressed urinary proteins using a proteomics approach. They were serum albumins, AMBP proteins, negative trypsin, elastase, and urinary protein, GAPDH, a receptor of urokinase-type plasminogen activator (uPAR), and Ig kappa chain C region. We used the electronic nose to quickly detect changes in the volatile substances in mice urine after holothurian polypeptides (HPP) fed, and the results show it can identify the difference between treatment groups with the control group without overlapping. The protein express mechanism of HPP treating diabetes was discussed, and we suggested these two peptides with the hypoglycemic and renal protective activity might be utilized as nutraceuticals.

PubMed ID: 28798909
PMC ID: PMC5526924
Article link: Front Chem


Genes referenced: LOC100887844


Article Images: [+] show captions
References [+] :
Adrian, Hypotrypsinaemia in diabetes mellitus. 1979, Pubmed