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Dev Biol
2009 Apr 15;3282:221-33. doi: 10.1016/j.ydbio.2009.01.027.
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Chordin is required for neural but not axial development in sea urchin embryos.
Bradham CA
,
Oikonomou C
,
Kühn A
,
Core AB
,
Modell JW
,
McClay DR
,
Poustka AJ
.
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The oral-aboral (OA) axis in the sea urchin is specified by the TGFbeta family members Nodal and BMP2/4. Nodal promotes oral specification, whereas BMP2/4, despite being expressed in the oral territory, is required for aboral specification. This study explores the role of Chordin (Chd) during sea urchin embryogenesis. Chd is a secreted BMP inhibitor that plays an important role in axial and neural specification and patterning in Drosophila and vertebrate embryos. In Lytechinus variegatus embryos, Chd and BMP2/4 are functionally antagonistic. Both are expressed in overlapping domains in the oral territory prior to and during gastrulation. Perturbation shows that, surprisingly, Chd is not involved in OA axis specification. Instead, Chd is required both for normal patterning of the ciliary band at the OA boundary and for development of synaptotagmin B-positive (synB) neurons in a manner that is reciprocal with BMP2/4. Chd expression and synB-positive neural development are both downstream from p38 MAPK and Nodal, but not Goosecoid. These data are summarized in a model for synB neural development.
Amore,
Spdeadringer, a sea urchin embryo gene required separately in skeletogenic and oral ectoderm gene regulatory networks.
2003, Pubmed,
Echinobase
Amore,
Spdeadringer, a sea urchin embryo gene required separately in skeletogenic and oral ectoderm gene regulatory networks.
2003,
Pubmed
,
Echinobase
Angerer,
A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis.
2000,
Pubmed
,
Echinobase
Angerer,
Sea urchin goosecoid function links fate specification along the animal-vegetal and oral-aboral embryonic axes.
2001,
Pubmed
,
Echinobase
Angerer,
Sea urchin metalloproteases: a genomic survey of the BMP-1/tolloid-like, MMP and ADAM families.
2006,
Pubmed
,
Echinobase
Bachiller,
The organizer factors Chordin and Noggin are required for mouse forebrain development.
2000,
Pubmed
Bachiller,
The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome.
2003,
Pubmed
Bradham,
The sea urchin kinome: a first look.
2006,
Pubmed
,
Echinobase
Bradham,
p38 MAPK is essential for secondary axis specification and patterning in sea urchin embryos.
2006,
Pubmed
,
Echinobase
Burke,
Neuron-specific expression of a synaptotagmin gene in the sea urchin Strongylocentrotus purpuratus.
2006,
Pubmed
,
Echinobase
Cameron,
The embryonic ciliated band of the sea urchin, Strongylocentrotus purpuratus derives from both oral and aboral ectoderm.
1993,
Pubmed
,
Echinobase
Choi,
Overexpression of calbindin-D28K induces neurite outgrowth in dopaminergic neuronal cells via activation of p38 MAPK.
2001,
Pubmed
Croce,
Coquillette, a sea urchin T-box gene of the Tbx2 subfamily, is expressed asymmetrically along the oral-aboral axis of the embryo and is involved in skeletogenesis.
2003,
Pubmed
,
Echinobase
Dal-Pra,
Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity.
2006,
Pubmed
Davidson,
A genomic regulatory network for development.
2002,
Pubmed
,
Echinobase
Duboc,
Nodal and BMP2/4 signaling organizes the oral-aboral axis of the sea urchin embryo.
2004,
Pubmed
,
Echinobase
Ferguson,
Localized enhancement and repression of the activity of the TGF-beta family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo.
1992,
Pubmed
Flowers,
Nodal/activin signaling establishes oral-aboral polarity in the early sea urchin embryo.
2004,
Pubmed
,
Echinobase
Francois,
Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene.
1994,
Pubmed
Gross,
LvTbx2/3: a T-box family transcription factor involved in formation of the oral/aboral axis of the sea urchin embryo.
2003,
Pubmed
,
Echinobase
Hammerschmidt,
Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor.
1996,
Pubmed
Hammerschmidt,
dino and mercedes, two genes regulating dorsal development in the zebrafish embryo.
1996,
Pubmed
Hansen,
Cyclic AMP-induced neuronal differentiation via activation of p38 mitogen-activated protein kinase.
2000,
Pubmed
Hansen,
Direct neural induction and selective inhibition of mesoderm and epidermis inducers by Xnr3.
1997,
Pubmed
Haramoto,
Two distinct domains in pro-region of Nodal-related 3 are essential for BMP inhibition.
2006,
Pubmed
Haramoto,
Xenopus tropicalis nodal-related gene 3 regulates BMP signaling: an essential role for the pro-region.
2004,
Pubmed
Hardin,
Commitment along the dorsoventral axis of the sea urchin embryo is altered in response to NiCl2.
1992,
Pubmed
,
Echinobase
Hemmati-Brivanlou,
Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity.
1994,
Pubmed
Holley,
A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin.
1995,
Pubmed
Hwang,
Characterization of a homolog of human bone morphogenetic protein 1 in the embryo of the sea urchin, Strongylocentrotus purpuratus.
1994,
Pubmed
,
Echinobase
Iemura,
Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo.
1998,
Pubmed
Ishii,
Integrin-linked kinase controls neurite outgrowth in N1E-115 neuroblastoma cells.
2001,
Pubmed
Iwasaki,
Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2.
1999,
Pubmed
Khokha,
Depletion of three BMP antagonists from Spemann's organizer leads to a catastrophic loss of dorsal structures.
2005,
Pubmed
Kuroda,
Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, beta-Catenin, and Cerberus.
2004,
Pubmed
Lapraz,
RTK and TGF-beta signaling pathways genes in the sea urchin genome.
2006,
Pubmed
,
Echinobase
Lepage,
Spatial and temporal expression pattern during sea urchin embryogenesis of a gene coding for a protease homologous to the human protein BMP-1 and to the product of the Drosophila dorsal-ventral patterning gene tolloid.
1992,
Pubmed
,
Echinobase
Little,
Extracellular modulation of BMP activity in patterning the dorsoventral axis.
2006,
Pubmed
Masucci,
Pattern-specific expression of the Drosophila decapentaplegic gene in imaginal disks is regulated by 3' cis-regulatory elements.
1990,
Pubmed
Minokawa,
Expression patterns of four different regulatory genes that function during sea urchin development.
2004,
Pubmed
,
Echinobase
Morooka,
Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells.
1998,
Pubmed
Nakajima,
Divergent patterns of neural development in larval echinoids and asteroids.
2004,
Pubmed
,
Echinobase
Nam,
Cis-regulatory control of the nodal gene, initiator of the sea urchin oral ectoderm gene network.
2007,
Pubmed
,
Echinobase
Oelgeschläger,
Chordin is required for the Spemann organizer transplantation phenomenon in Xenopus embryos.
2003,
Pubmed
Oliveri,
Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo.
2006,
Pubmed
,
Echinobase
Piccolo,
Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.
1996,
Pubmed
Piccolo,
Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity.
1997,
Pubmed
Posakony,
Wing formation in Drosophila melanogaster requires decapentaplegic gene function along the anterior-posterior compartment boundary.
1990,
Pubmed
Poustka,
On the origin of the chordate central nervous system: expression of onecut in the sea urchin embryo.
2004,
Pubmed
,
Echinobase
Poustka,
Generation, annotation, evolutionary analysis, and database integration of 20,000 unique sea urchin EST clusters.
2003,
Pubmed
,
Echinobase
Poustka,
A global view of gene expression in lithium and zinc treated sea urchin embryos: new components of gene regulatory networks.
2007,
Pubmed
,
Echinobase
Range,
Cis-regulatory analysis of nodal and maternal control of dorsal-ventral axis formation by Univin, a TGF-beta related to Vg1.
2007,
Pubmed
,
Echinobase
Rentzsch,
Asymmetric expression of the BMP antagonists chordin and gremlin in the sea anemone Nematostella vectensis: implications for the evolution of axial patterning.
2006,
Pubmed
Reynolds,
Early mRNAs, spatially restricted along the animal-vegetal axis of sea urchin embryos, include one encoding a protein related to tolloid and BMP-1.
1992,
Pubmed
,
Echinobase
Samanta,
The transcriptome of the sea urchin embryo.
2006,
Pubmed
,
Echinobase
Sasai,
Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes.
1994,
Pubmed
Sasai,
Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus.
1995,
Pubmed
Shen,
The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary.
2005,
Pubmed
Shimmi,
Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo.
2003,
Pubmed
Shimmi,
Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo.
2005,
Pubmed
Smith,
Roles of BMP signaling and Nkx2.5 in patterning at the chick midgut-foregut boundary.
2000,
Pubmed
Smith,
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos.
1992,
Pubmed
Sodergren,
The genome of the sea urchin Strongylocentrotus purpuratus.
2006,
Pubmed
,
Echinobase
Takacs,
Expression of an NK2 homeodomain gene in the apical ectoderm defines a new territory in the early sea urchin embryo.
2004,
Pubmed
,
Echinobase
Takeda,
Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells.
2000,
Pubmed
Wang,
Spatial bistability of Dpp-receptor interactions during Drosophila dorsal-ventral patterning.
2005,
Pubmed
Wei,
A database of mRNA expression patterns for the sea urchin embryo.
2006,
Pubmed
,
Echinobase
Yaguchi,
Specification of ectoderm restricts the size of the animal plate and patterns neurogenesis in sea urchin embryos.
2006,
Pubmed
,
Echinobase
Yaguchi,
A Wnt-FoxQ2-nodal pathway links primary and secondary axis specification in sea urchin embryos.
2008,
Pubmed
,
Echinobase
Yaguchi,
Sp-Smad2/3 mediates patterning of neurogenic ectoderm by nodal in the sea urchin embryo.
2007,
Pubmed
,
Echinobase
Yeo,
Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms.
2001,
Pubmed
Zimmerman,
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.
1996,
Pubmed
