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Echinobase
ECB-ART-52879
Int J Mol Sci 2024 Jan 30;253:. doi: 10.3390/ijms25031685.
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De Novo Assembly of the Genome of the Sea Urchin Paracentrotus lividus (Lamarck 1816).

Costantini M , Esposito R , Ruocco N , Caramiello D , Cordella A , Ventola GM , Zupo V .


Abstract
The Mediterranean purple sea urchin Paracentrotus lividus (Lamarck 1816) is a remarkable model system for molecular, evolutionary and cell biology studies, particularly in the field of developmental biology. We sequenced the genome, performed a de novo assembly, and analysed the assembly content. The genome of P. lividus was sequenced using Illumina NextSeq 500 System (Illumina) in a 2 × 150 paired-end format. More than 30,000 open reading frames (ORFs), (more than 8000 are unique), were identified and analysed to provide molecular tools accessible for the scientific community. In particular, several genes involved in complex innate immune responses, oxidative metabolism, signal transduction, and kinome, as well as genes regulating the membrane receptors, were identified in the P. lividus genome. In this way, the employment of the Mediterranean sea urchin for investigations and comparative analyses was empowered, leading to the explanation of cis-regulatory networks and their evolution in a key developmental model occupying an important evolutionary position with respect to vertebrates and humans.

PubMed ID: 38338963
Article link: Int J Mol Sci



References [+] :
Adonin, Sea Urchin as a Universal Model for Studies of Gene Networks. 2020, Pubmed, Echinobase