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ECB-ART-46897
Nat Prod Res 2020 Apr 01;348:1061-1067. doi: 10.1080/14786419.2018.1548451.
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Triterpene glycosides from the Vietnamese sea cucumber Holothuria edulis.

Hoang L , Le Thi V , Tran Thi Hong H , Nguyen Van T , Nguyen Xuan C , Nguyen Hoai N , Do Cong T , Ivanchina NV , Do Thi T , Dmitrenok PS , Kicha AA , Phan Van K , Chau Van M .


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From the MeOH extract of the Vietnamese sea cucumber Holothuria edulis, eight triterpene glycosides (1-8), including one new compound namely holothurin A5 (1), were isolated by using various chromatographic separations. Their structures were established by spectroscopic experiments including 1D, 2D NMR and HR-ESI-MS. Holothurin A5 (1) has a hydroperoxy group at C-25. To the best of our knowledge, this is the first report of this group in triterpene saponins obtained from sea cucumbers to date. In addition, the in vitro cytotoxicity against five human cancer cell lines (HepG2, KB, LNCaP, MCF7 and SK-Mel2) of all isolated compounds was also evaluated using SRB assays.

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Genes referenced: LOC100887844 LOC100893907 LOC115919910