Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-39567
Acta Histochem 2005 Jan 01;1074:243-51. doi: 10.1016/j.acthis.2005.06.009.
Show Gene links Show Anatomy links

A novel approach to study adhesion mechanisms by isolation of the interacting system.

Coyle-Thompson C , Oppenheimer SB .


???displayArticle.abstract???
For decades most investigations into mechanisms of adhesive interactions have examined whole organisms or single cells. Results using whole organisms are often unclear because it may not be known if a probe used in an experiment is directly affecting the cellular interaction under study or if it is an indirect effect resulting from action on some other structure or pathway. Here we develop a novel approach to isolate the structural components of a cellular interaction by dissecting them out of the organism to study them in a pristine environment away from all confounding factors. We used the adhesion between the archenteron and blastocoel roof of the sea urchin gastrula stage embryo as a model that can be replicated in many other developmental and pathological systems. The isolated components of the cellular interaction and those in the whole organism possessed identical cell surface receptors and adhesive affinities.

???displayArticle.pubmedLink??? 16181663
???displayArticle.pmcLink??? PMC1857332
???displayArticle.link??? Acta Histochem
???displayArticle.grants??? [+]

Genes referenced: LOC100887844 LOC115919910

References [+] :
Akasaka, Scanning electron microscopical study of the inside of sea urchin embryos (Pseudocentotus depressus). Effects of Aryl beta-xyloside, tunicamycin and deprivation of sulfate tions. 1980, Pubmed, Echinobase