ECB-ART-39567
Acta Histochem
2005 Jan 01;1074:243-51. doi: 10.1016/j.acthis.2005.06.009.
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A novel approach to study adhesion mechanisms by isolation of the interacting system.
Coyle-Thompson C
,
Oppenheimer SB
.
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For decades most investigations into mechanisms of adhesive interactions have examined whole organisms or single cells. Results using whole organisms are often unclear because it may not be known if a probe used in an experiment is directly affecting the cellular interaction under study or if it is an indirect effect resulting from action on some other structure or pathway. Here we develop a novel approach to isolate the structural components of a cellular interaction by dissecting them out of the organism to study them in a pristine environment away from all confounding factors. We used the adhesion between the
archenteron and
blastocoel roof of the sea urchin gastrula stage
embryo as a model that can be replicated in many other developmental and pathological systems. The isolated components of the cellular interaction and those in the whole organism possessed identical cell surface receptors and adhesive affinities.
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16181663
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PMC1857332
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Acta Histochem
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Genes referenced:
LOC100887844
LOC115919910
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